Comparative research of MR imaging between rheumatoid arthritis and osteoarthritis of the knee and correlation with histopathology

LIU Qian; ZHANG Xue-ning; WANG Zhi; XU Jin; MENG Xiang-hong

Journal of China Clinic Medical Imaging ›› 2014, Vol. 25 ›› Issue (8) : 587-591.

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Comparative research of MR imaging between rheumatoid arthritis and osteoarthritis of the knee and correlation with histopathology

LIU Qian1, ZHANG Xue-ning1, WANG Zhi2, XU Jin2, MENG Xiang-hong2

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Abstract

Objective: To analyze and compare the MRI and pathologic characteristics between rheumatoid arthritis(RA) and osteoarthritis(OA) of the knee, exploring the pathological mechanism of RA. Methods: Fourteen knees in 12 patients with RA and 10 knees in 10 patients with OA were treated by total knee arthroplasty(TKA), which was also correlative with MRI. Results: There was no statistical significance of the injury in articular cartilage of medial tibiofemoral joints and patellofemoral joints between RA and OA(P＞0.05). The injure in articular cartilage of lateral tibiofemoral joints of the knee in RA group was significanily high and more severe than that of the knee in OA group(P＜0.05). The subchondral bone marrow lesions of medial and lateral tibiofemoral joints of the knee in RA group was significanily severe than that of the knee in OA group(P＜0.05). The injury of medial and lateral menisci of the knee in RA group was significanily severe than that of the knee in OA group(P＜0.05). There were a large number of inflammatory cells and blood vessels in the articular cartilage, subchondral bone marrow and menisci in the knee of RA group. While articular cartilage fibrosis and only few inflammayory cells and blood vessels were found in OA group. Conclusions: The degree of destruction of all parts in the knee in RA group was significantly higher than those in OA group, this may be related to vasculitis.

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Arthritis / rheumatoid / Osteoarthritis / Magnetic resonance imaging

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LIU Qian;ZHANG Xue-ning;WANG Zhi;XU Jin;MENG Xiang-hong. Comparative research of MR imaging between rheumatoid arthritis and osteoarthritis of the knee and correlation with histopathology[J]. Journal of China Clinic Medical Imaging. 2014, 25(8): 587-591