Objective: To evaluate the therapeutic effect of aerobic exercise in patients with Alzheimer’s disease(AD) quantitatively by functional magnetic resonance imaging(fMRI). Methods: Seventeen cases of patients with AD were randomly divided into training group(9 cases) and control group(8 cases). The fMRI data of baseline and 3 months later were got for the amplitude of low frequency fluctuation(ALFF) analysis and analysis of brain functional network. Results: The training group showed increased ALFF value of bilateral prefrontal and anterior cingulate cortex and brain network between centrality(BC) value compared with baseline after 3 months of training, while the BC value of training group was higher than those in control group after 3 months. The difference was statistically significant(P<0.05). Further analysis of the network hubs showed bilateral distribution after training, which was different from the asymmetric distribution before. Conclusion: Resting-state fMRI data suggest that aerobic exercise is helpful to recovery of cognitive function in patients with AD, providing a quantitative evaluation method of effectiveness.
Key words
Alzheimer disease /
Magnetic resonance imaging
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1]况伟宏，李进，黄明生，等． 轻度阿尔茨海默病行为障碍的临床研究[J]． 中国行为医学科学，2002，11（6）：635-636．
[2]陈强． 综合康复训练对轻中度阿尔茨海默病的辅助效果[J]． 中国行为医学科学，2004，13（3）：308．
[3]付婧，肖军． 阿尔茨海默病言语障碍的药物干预和康复训练[J]． 实用医院临床杂志，2012，9（3）：182-184．
[4]龙淼淼，倪红艳，祁吉，等． 采用MR低频振幅图像和低频振幅分数图像观察阿尔茨海默病患者静息态脑功能改变[J]． 中华放射学杂志，2013，47（1）：44-48．
[5]Salvador R. Neurophysiological architecture of functional magnetic resonance images of human brain[J]. Cereb Cortex, 2005, 15(9): 1332-1342.
[6]武江芬，钱志余，陶玲，等． 静息态脑功能网络中核心节点的定位及其方法比较[J]． 生物医学工程研究，2013，32（3）：1-4．
[7]赵会力，彭华，张秀萍，等． 康复疗法治疗老年性痴呆临床观察[J]． 中国现代医学杂志，2000，10（9）：96．
[8]谭晓雪，罗玉玲，陈少梅，等． 康复训练对早、中期老年性痴呆患者认知功能障碍的影响[J]． 中国老年学杂志，2012，32（18）：3876-3878．
[9]李爱云，李秀艳． 综合认知训练对阿尔茨海默病患者心境的影响[J]． 中国实用护理杂志，2013，29（6）：10-13．
[10]刘月平，徐永涛，扶治霞． 综合康复治疗对轻、中度阿尔茨海默病的疗效观察[J]． 中国康复，2013，28（5）：373-374．
[11]刘学成． 早期老年性痴呆患者社区康复训练干预效果[J]． 职业与健康，2014，30（3）：396-398．
[12]Erickson KI, Voss MW, Prakash RS, et al. Exercise training increases size of hippocampus and improves memory[J]. Proc Natl Acad Sci USA, 2011, 108(7): 3017-3022.
[13]Vidoni ED, Honea RA, Billinger SA, et al. Cardiorespiratory fitness is associated with atrophy in Alzheimer’s and aging over 2 years[J]. Neurobiol Aging, 2012, 33(8): 1624-1632.
[14]Cabeza R. Hemispheric asymmetry reduction in older adults: the HAROLD model[J]. Psychol Aging, 2002, 17(1): 85-100.
[15]Cabeza R, Nicole D, Jill K, et al. Aging gracefully: compensatory brain activity in high-performing older adults[J]. Neuro Image, 2002, 17(3): 1394-1402.
[16]Buckner RL, Sepulcre J, Talukdar T, et al. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer’s disease[J]. J Neurosci, 2009, 29(6): 1860-1873.
