Correlation between contrast-enhanced ultrasound characteristics and microvessel density ofbenign and malignant thyroid nodules

LI Xiao-peng; ZHANG Hong-li; HE Xin; ZHOU Qi; JIANG Jue; GAO Ya; LEI Xiao-ying

Journal of China Clinic Medical Imaging ›› 2015, Vol. 26 ›› Issue (9) : 631-634.

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Correlation between contrast-enhanced ultrasound characteristics and microvessel density ofbenign and malignant thyroid nodules

LI Xiao-peng, ZHANG Hong-li, HE Xin, ZHOU Qi, JIANG Jue, GAO Ya, LEI Xiao-ying

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Abstract

Objective: To investigate the performance of thyroid nodules with contrast-enhanced ultrasound(CEUS) and the correlation between CEUS quantitative parameters and microvessel density(MVD), to provide pathologic basis for different perfusion characteristics of benign and malignant thyroid nodules. Methods: The CEUS features of 122 patients with thyroid nodules were retrospectively analyzed. The time-intensity curves(TIC) were analyzed by TomTec software. Immunohistochemical staining were performed to evaluate the MVD in the surgical specimens, and the correlation of quantitative parameters with MVD were assessed. Results: When the ultrasound contrast enhancement to the peak, the thyroid carcinoma showed homogeneous hypo-enhancement, nodular goiter showed iso-enhancement, thyroid adenoma showed hyper-enhancement. IMAX and MVD of thyroid carcinoma were lower than nodular goiter and thyroid adenoma, and the differences were statistically significant(P<0.05). A positive correlation existed between the IMAX and MVD(rCD31=0.814，PCD31＜0.01; rCD34=0.803, PCD34＜0.01). Conclusions: Hypo-enhancement was the important CEUS enhancement patterns to diagnose thyroid carcinoma, thyroid carcinoma was lack of blood supply.

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Thyroid nodule / Ultrasonography / Doppler / color

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LI Xiao-peng;ZHANG Hong-li;HE Xin;ZHOU Qi;JIANG Jue;GAO Ya;LEI Xiao-ying. Correlation between contrast-enhanced ultrasound characteristics and microvessel density ofbenign and malignant thyroid nodules[J]. Journal of China Clinic Medical Imaging. 2015, 26(9): 631-634