Preliminary study on assessment of regadenoson-induced blood-brain barrier opening by MR perfusion weighted imaging

CHANG Can-can1; ZHOU Jun2; YANG Ben-qiang1; LI Hong-yi1; XU Zhi-hua1; LIN Sen1; DUAN Yang1

Journal of China Clinic Medical Imaging ›› 2016, Vol. 27 ›› Issue (10) : 690-693.

CHANG Can-can1, ZHOU Jun2, YANG Ben-qiang1, LI Hong-yi1, XU Zhi-hua1, LIN Sen1, DUAN Yang1

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Abstract

Objective: To evaluate the level of regadenoson-induced blood-brain barrier opening of healthy rabbits via MR perfusion weighted imaging(MR PWI) scan. Methods: Fifty New Zealand white rabbits were randomly divided into experimental group(group A) and control group(group B). The regadenoson and normal saline were injected intravenously into ear margin separately, after 10 minute, MR PWI scan was performed. Then rCBF, rCBV, TTP and MTT of the region of interest of each group were acquired and compared statistically(paired t test). Five cases of each group choosed randomly were injected with 2% Evens blue intravenously posterior to imaging. After one hour of infusion, all the animals were killed. Their brains were examined for the determination of Evens blue distribution. Results: The rCBF and rCBV values and the staining with Evens blue of group A were significantly higher than those of group B(P<0.05). There were no significant differences of TTP and MTT values between group A and B(P>0.05). Conclusion: The parameters(rCBF, rCBV) of MR PWI scan can monitor the level of regadenoson-induced blood-brain barrier opening in vivo.

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Blood-brain barrier / Magnetic resonance imaging

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CHANG Can-can1, ZHOU Jun2, YANG Ben-qiang1, LI Hong-yi1, XU Zhi-hua1, LIN Sen1, DUAN Yang1. Preliminary study on assessment of regadenoson-induced blood-brain barrier opening by MR perfusion weighted imaging[J]. Journal of China Clinic Medical Imaging. 2016, 27(10): 690-693

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