Objective: To evaluate the efficacy and safety of transcatheter local thrombolysis in treatment of acute embolic renal artery occlusion. Materials and Methods: A retrospective analysis of 13 patients with acute embolic renal artery occlusion and interventional treatment. In all patients, digital subtraction angiography(DSA) was performed to confirm the suspected diagnosis, followed by selective catheterization of the renal artery to identify the occlusion type. Thrombolytic therapy was performed by urokinase with regional catheter delivery by means of infusion pump, and renal artery angiography repeated daily. Regular follow-up after discharge. Results: All patients completed the emergency renal arteriography and catheterization, thrombolytic therapy process lasts 24 to 120 hours without any serious complications. The total amount of urokinase was 0.6 million units to 3 million units. Renal artery recanalization was achieved in 6 cases with the main renal artery embolization and 3 cases with renal artery branches embolization, and there was poor efficacy in 1 patient with main renal artery and 3 patients with renal artery branches embolization. One patient was found renal artery stenosis after thrombolysis, and a renal artery stent placement was performed. The flank pain symptoms were relieved in all patients. There was no recurrence during 6~40 months followed up. Conclusion: In acute embolic renal artery occlusion, transcatheter local thrombolysis is a safe and effective treatment which may recover renal blood flow effectively, relieve the symptoms of patients.