Multi-modality MRI study about the impact of human urinary kallidinogenase on collateral circulation and #br# blood perfusion in patients with acute cerebral infarction

Journal of China Clinic Medical Imaging ›› 2016, Vol. 27 ›› Issue (2) : 77-81.

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Abstract

Objective: To explore the impact of human urinary kallidinogenase(HUK) on collateral circulation and blood perfusion in patients with acute cerebral infarction in order to find a new kind of medicine with great efficiency in building collateral circulation and saving ischaemic penumbra. Methods: Forty patients with acute cerebral infarction of middle cerebral artery(MCA) were selected in the study and divided into two groups with the randomized controlled method. Each group included twenty patients. Diffusion weighted imaging(DWI) and perfusion weighted imaging(PWI) images of all the participants were collected one day before treatment, the seventh day and the thirtieth day after treatment. We first compared the differences of blood perfusion in ischaemic core and ischaemic penumbra before and after treatment between the two groups. Then we compared the establishment of collateral circulation in peripheral regions of infarction between the two groups using contrast enhance MRA(CE-MRA) technology. Results: ①Compared with before treatment, the regional cerebral blood flow(rCBF) value in ischaemic core and ischaemic penumbra of both the groups increased significantly after treatment. However, group with HUK treatment had a more obvious increase of rCBF value in ischaemic tissues and the differences of rCBF value after treatment between the two groups are statistically significant(ischaemic core: 0.86±0.43 vs 0.54±0.13, P<0.05; ischaemic penumbra: 2.11±0.36 vs 1.03±0.61, P<0.05). ②Using CE-MRA, the establishment of leptomeningeal collateral circulation in lateral fissure and lateral surface of hemishere was showed and the grade of collateral circulation in group with HUK treatment improved significantly(4.3±0.5 vs 3.2±0.7, P<0.05). Conclusion: HUK can efficiently improve collateral circulation and blood perfusion of ischaemic tissues in patients with acute cerebral infarction. CE-MRA technology is likely to be a new method for evaluating the establishment of collateral vessels.

Key words

Brain infarction / Urinary plasminogen activator / Collateral circulation / Magnetic resonance imaging

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SHENG Can1, LI Yu-xia1, XIE Yun-yan1, ZHANG Zhong-min2, SUN Yu1, WANG Xiao-ni1, LI Hong-yan1,. Multi-modality MRI study about the impact of human urinary kallidinogenase on collateral circulation and #br# blood perfusion in patients with acute cerebral infarction[J]. Journal of China Clinic Medical Imaging. 2016, 27(2): 77-81

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