Relationships between NOX4 expression and 18F-FDG uptake in patients with breast cancer

LI Xue-na; YIN Ya-fu; DU Bu-lin; LI Ya-ming

Journal of China Clinic Medical Imaging ›› 2016, Vol. 27 ›› Issue (8) : 547-550.

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Abstract

Objective: The relationship between the NOX4(NADPH oxidase 4) expression and glucose metabolism in breast cancer is unclear. This present study intends to study the expression levels of NOX4 and 18F-FDG uptake. And to further explore the clinical significance. Methods: The patients diagnosed as breast cancer who underwent preoperative 18F-FDG PET were enrolled. We examined the maximum standardized uptake values(SUVmax) of lesions. The levels of NOX4 were measured with immunohistochemical analysis. The clinical, histopathology of breast cancer patients were collected and recorded, and the correlation between NOX4 and clinical and histological predictors and metastasis were analyzed. Results: Fifty-six patients met the inclusion criteria and were included in the study, a total of 56 breast lesions. The SUVmax of lesions were 4.78±2.96. Thirty-three cases had positive expression of NOX4, 23 cases had negative expression. The SUVmax in the positive expression of NOX4 group was 6.42±3.23, the negative NOX expression group was 3.22±1.57. The SUVmax was higher in the NOX4 positive expression group than negative expression group, the difference was statistically significant(t=4.83, P<0.05). NOX4 expression levels were significantly correlated with lymph node metastasis(χ2=4.52, P<0.05). The expression of NOX4 and histological types have no significant correlation(χ2=2.88, P>0.05). The expression of NOX4 and histological grading were significantly related to histological grade, the positive rate of NOX4 expression in the group Ⅲ was higher than Ⅰ+Ⅱ Group(χ2=6.32, P<0.01). The SUVmax in infiltrating ductal carcinoma was higher than lobular carcinoma(t=2.97, P<0.05). The SUVmax in lymph node metastasis was higher than no lymph node metastasis(t=2.04, P=0.04). The SUVmax in the group Ⅲ was higher than Ⅰ+Ⅱ Group(t=-2.5, P<0.05). Conclusions: The levels of NOX4 expression were correlated with the 18F-FDG uptake. The expression of NOX4 and the 18F-FDG uptake are associated with lymph node metastasis and histological grade.

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Breast neoplasms / Fluorodeoxyglucose F18 / Positron-emission tomography

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LI Xue-na, YIN Ya-fu, DU Bu-lin, LI Ya-ming. Relationships between NOX4 expression and 18F-FDG uptake in patients with breast cancer[J]. Journal of China Clinic Medical Imaging. 2016, 27(8): 547-550

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