Effect of levetiracetam in benign childhood epilepsy with centro-temporal spikes: #br#
a resting-state fMRI study based on amplitude of low frequence fluctuation

LI Zhi-peng1; YANG Fang1; HU Zheng2; ZHANG Qi-rui1; QUAN Wei1; XU Qiang1; ZHANG Zhi-qiang1; LU Guang-ming1

Journal of China Clinic Medical Imaging ›› 2017, Vol. 28 ›› Issue (10) : 707-711.

Effect of levetiracetam in benign childhood epilepsy with centro-temporal spikes: #br# a resting-state fMRI study based on amplitude of low frequence fluctuation

LI Zhi-peng1, YANG Fang1, HU Zheng2, ZHANG Qi-rui1, QUAN Wei1, XU Qiang1, ZHANG Zhi-qiang1, LU Guang-ming1

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Abstract

Objective: To use amplitude of low frequence fluctuation(ALFF) to evaluate the brain functional change of benign childhood epilepsy with centro-temporal spikes(BECTS) and the influence of levetiracetam(LEV) on BECTS. Methods: Twenty-two BECTS treated with LEV, twenty-two BECTS with no treatment and twenty-two age and sex-matched healthy children were included to preform functional magnetic resonance imaging(fMRI). After data preprocessing, the difference of ALFF among the three groups was obtained by the analysis of variance, and their correlation with clinical index were reported. Results: Compared to the healthy group, the ALFF of bilateral Rolandic areas in both untreated group and the LEV group were increased. And compared to the non-treatment group, the ALFF of bilateral Rolandic areas in the LEV group were decreased. The ALFF of left precentral/postcentral gyrus and left inferior frontal gyrus showed positive correlation with the duration of untreated BECTS, while the left precentral gyrus and the right superior frontal gyrus showed negative correlation with the duration of the LEV effects and the left precuneus and right middle temporal gyrus showed a positive correlation with the duration of the LEV effects in LEV group. Conclusion: The discharge areas of BECTS in brain show increased activities, and LEV can effectively reduce the intrinsic brain activity in these areas of BECTS and impact on the areas about language, attention and default mode network(DMN). These evidences based on fMRI show that LEV is useful in the treatment of BECTS.

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Epilepsy / Child / Magnetic resonance imaging

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LI Zhi-peng1, YANG Fang1, HU Zheng2, ZHANG Qi-rui1, QUAN Wei1, XU Qiang1, ZHANG Zhi-qiang1, LU Guang-ming1. Effect of levetiracetam in benign childhood epilepsy with centro-temporal spikes: #br# a resting-state fMRI study based on amplitude of low frequence fluctuation[J]. Journal of China Clinic Medical Imaging. 2017, 28(10): 707-711

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