Objective: To study the 3.0T multivoxel proton magnetic spectroscopy(1H-MRS) findings in brain glioma and to investigate the correlation between Cho/Cr ratio and expression of Ki-67. Methods: Fifty-seven patients of brain gliomas were studied, including 28 cases of low-grade group(grade Ⅰ~Ⅱ), 29 cases of high-grade group(grade Ⅲ~Ⅳ). All of them underwent 3.0T 1H-MRS examination before operation. The Cho/Cr ratios were detected. We analyzed the correlation between Cho/Cr ratio and pathological grade of gliomas. Ki-67 immunohistochemical staining and Ki-67 labeling index(Ki-67LI) were measured after operation. We also analyzed the correlation between Ki-67LI and the pathological grade, the Cho/Cr ratio of gliomas. Results: ①Significant differences were found in the ratios of Cho/Cr between low grade gliomas and high grade gliomas(P<0.001). The ratio of Cho/Cr was positively correlated with the tumor grade(r=0.616, P<0.001). The area under the curve(AUC) of Cho/Cr was 0.856. The threshold value of Cho/Cr ratio for differential diagnosis high grade and low grade brain gliomas was 2.44, the sensitivity was 79.3%, the specificity was 82.1%. ②Ki-67LI of low grade glioma was (3.41±2.35)%, Ki-67LI of high grade glioma was (19.78±11.45)%, the difference was statistically significant(Z=-0.617, P<0.001). The Ki-67LI was positively correlated with the tumor grade and the Cho/Cr ratio(r=0.804, P<0.001). Conclusion: The Cho/Cr ratios of gliomas are correlated with the expression of Ki-67. It may be a useful image index, which can evaluate the proliferation activity and malignancy degree of glioma, without invasion. And it may be helpful in the clinical treatment and prognosis assessment.
Key words
Glioma /
Ki-67 antigen /
Magnetic resonance imaging
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