A preliminary study on predicting the prognostic high-risk factors of cervical squamous cell carcinoma after neoadjuvant chemotherapy by CT perfusion imaging

YIN Liang; LEI Jun-qiang; GUO Ji-gang; ZHAI Ya-nan; DOU Yu

Journal of China Clinic Medical Imaging ›› 2017, Vol. 28 ›› Issue (5) : 350-353.

YIN Liang, LEI Jun-qiang, GUO Ji-gang, ZHAI Ya-nan, DOU Yu

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Objective: To explore the predictive value of CT perfusion imaging for predicting the prognostic high-risk factors of cervical squamous carcinoma after neoadjuvant chemotherapy. Methods: The 51 patients who had cervical squamous carcinoma and underwent neoadjuvant chemotherapy before surgery between 2011 May and 2015 August in the First Hospital of Lanzhou University were selected. Based on the prognostic high-risk factors of pathology test and short-term prognosis, the cases were divided into two groups: non-high-risk factors(n=36, 70.59%) and high-risk group(n=15, 29.41%). CT perfusion parameters and clinical data were retrospectively analyzed to investigate the high-risk prognostic factors. Results: Two indexes of the high-risk group cases, the BF(blood flow) and the maximum diameter of the tumor post chemotherapy, were statistically significant higher than another group(P<0.05). The high-risk prognostic factors were positively correlated with BF and the maximum diameter of tumor after neoadjuvant chemotherapy(r=0.420, P=0.002; r=0.296, P=0.035). FIGO staging, pathological grade, the initial diameter of the tumor, BV, permeability and TTP were not correlated with the high-risk prognostic factors(P>0.05). Multivariate logistic regressionn analysis showed BF was an independent predictor to predict the existence of high-risk prognostic factors in cervical squamous carcinoma after neoadjuvant chemotherapy. BF can predict the?prognostic results accurately AUC=0.810, P=0.001, 95%CI(0.682~0.918). Conclusion: BF had significant predictive value as a prognostic high-risk factor of cervical squamous carcinoma after neoadjuvant chemotherapy. Using BF equal to or greater than 46.64 mL/(100mL·min) to predict the existence of high-risk prognostic factors got 86.67%(13/15), 94.44%(34/36) and 92.16%(47/51) in sensitivity, specificity and accuracy, respectively.

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YIN Liang, LEI Jun-qiang, GUO Ji-gang, ZHAI Ya-nan, DOU Yu. A preliminary study on predicting the prognostic high-risk factors of cervical squamous cell carcinoma after neoadjuvant chemotherapy by CT perfusion imaging[J]. Journal of China Clinic Medical Imaging. 2017, 28(5): 350-353

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