Objective: Analysis of clinical epidemiology characteristics of ankle fractures in adults, including fracture types and its distribution. To explore the relationship between these fractures and its mechanism of injury, and analysis of misdiagnosis of fracture and missed diagnosis. Methods: From January 2013 to December 2015 newly diagnosed adult patients with ankle fractures in the Third Hospital of Hebei Medical University were included in our research. The Danis-Weber Classification and Lauge-Hansen Classification were used to classify these fractures. Results: A total of 2 196 cases of ankle fractures, among them Weber type A accounted for 30%, Weber type B accounted for 42%, Weber type C accounted for 20%, vertical compression fractures accounted for 8%, 16~50 years old men accounted for 39%, women over 50 years of age accounted for 22%. There were 13 cases of missed diagnosis. The posterior malleolus, upper fibula and the lower front part of the tibia are prone to missed the fracture diagnosis. The missed diagnosis rate was 1.1%. Conclusion: Young men and older women have a relatively high preference for ankle fractures. Danis-Weber classification combined with Lauge-Hansen classification can help doctors to analyze the mechanism of injury and may predict the range of fractures involved. Thereby reduce the missed diagnosis of factures and improve the diagnostic accuracy.