Observation of the short-term efficacy for celecoxib as a sensitization agent for#br#
&nbsp;125I particles implantation in the treatment of lung cancer

LI Shuang; LIU Bao-ping; CHANG Wei; WANG Rui-hua; XIE Xin-li; CHENG Bing; HAN Xing-min; RUAN Qiao

Journal of China Clinic Medical Imaging ›› 2017, Vol. 28 ›› Issue (6) : 408-411.

Observation of the short-term efficacy for celecoxib as a sensitization agent for#br# 125I particles implantation in the treatment of lung cancer

LI Shuang, LIU Bao-ping, CHANG Wei, WANG Rui-hua, XIE Xin-li, CHENG Bing, HAN Xing-min, RUAN Qiao

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Abstract

Objective: To observe the short-term efficacy for celecoxib as a sensitization agent for 125I particles implantation in the treatment of lung cancer. Methods: Sixty-six patients with lung cancer were treated by CT guided interstitial 125I particles implantation． They were randomly divided into two groups(33 patients in test group, the other 33 in control group). The test group was given celecoxib on the same day of 125I particles implantation. The control group was only implanted with 125I particles. The local control of the tumor(complete relief+partial relief) was used as an evaluation standard of curative effect. Results: Among the 33 patients in the test group(125I particles implanted with celecoxib as radiotherapy sensitization agent), 3 patients had complete relief, 24 patients had partial relief, 3 patients had no effect and 3 patients had slight relief. The short-term effective rate was 81.8%. In the control group(33 cases with implanted 125I particles only): 1 patient had complete relief, 19 patients had partial relief, 3 patients had slight relief and 3 patients had no effect. The recent effective rate was 60.6%. The difference between the two groups was statistically significant(P<0.05). Conclusion: The treatment of celecoxib combined with 125I particles implantation for lung cancer has good radiotherapy sensitization effect. It improves the local control rate of tumor and has fewer side effects and is safe and effective.

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Lung neoplasms / Radionuclide imaging / Tomography, X-ray computed

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LI Shuang, LIU Bao-ping, CHANG Wei, WANG Rui-hua, XIE Xin-li, CHENG Bing, HAN Xing-min, RUAN Qiao. Observation of the short-term efficacy for celecoxib as a sensitization agent for#br# 125I particles implantation in the treatment of lung cancer[J]. Journal of China Clinic Medical Imaging. 2017, 28(6): 408-411

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