Objective: To evaluate the clinical value of multi-mode ultrasound blood technology for detecting microvascular in prostate lesions. Methods: Seventy prostate lesions from 50 patients before transrectal prostate biopsy were examined by color Doppler flow imaging(CDFI) and superb microvascular imaging(SMI), then contrast-enhance ultrasound(CEUS) were performed a standard to evaluate agreemnet of the microvascular perfusion of prostate lesions by three vascular imaging technique. Results: Vasculature detected by SMI was more highly correlated with the CEUS result at Kappa value of 0.72 than CDFI at Kappa value of 0.36. Conclusions: SMI technology could be used as the primary imaging method to evaluate vascularization in prostate lesion.