The consistency investigation of PET volume and MR volume for the cervical cancer using 18F-FDG PET/MR

LU Yue-yue; SUN Hong-zan; MA Quan-mei; XIN Jun

Journal of China Clinic Medical Imaging ›› 2018, Vol. 29 ›› Issue (2) : 112-117.

LU Yue-yue, SUN Hong-zan, MA Quan-mei, XIN Jun

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Abstract

Objective: In advanced cervical cancer radiotherapy target delineation, tumor volumes auto contoured by FDG PET scan change at different percentages of maximum standardized uptake value(SUVmax). To reduce such effect which interferes from PET and MR image fusion, we attempted to get a cutoff SUVmax at which the tumor volume correlates best with MRI volume on the primary tumors of cervical carcinoma. Methods: Patients with biopsy-proven cervical carcinomas(stages ⅡB and above) were included in this study and underwent pretreatment 18F-FDG PET/MRI. The dimensions were measured by two competent radiologists. Counters of the diseases were drawn in each slice on sagittal T2WI MR images, and volumes of the cervical carcinoma were calculated by tumor area multiplying slice profile. Volumes of the FDG PET scan at 20%～60%(with an interval of 5%) of SUVmax were auto calculated. Mean and median volumes of different SUVmax cutoff percentages on FDG-PET scan were recorded. Pearson correlation was used to analyze the correlation of MR and PET volumes at different thresholds with SPSS 17.0. The mean difference values between PET volumes at different thresholds and MR volumes were calculated, the difference between different SUVmax percentage PET volume and MR volume were analyzed by Student’s t test. Results: Data of 20 patients were available for the study. The mean MRI volume of the primary tumor was (40.5±28.0) cm3. The mean MRI volume correlates significantly(P＜0.001) with 35% SUVmax PET volume with good correlation according to the Pearson bivariate correlation(r=0.888, r2=0.789). The mean difference between MRI and PET volumes was the least at 35% SUVmax. There was no significant difference in the MRI and FDG-PET volumes obtained with SUVmax cutoff values of 35% SUVmax(P＞0.05) according to the Student’s t test. Conclusions: 18F-FDG PET-MR SUV-based primary tumor volume estimation at 35% SUVmax value correlates significantly with the criterion standard MR T2WI volumes for primary cervical tumor in our population. The difference of 35% SUVmax PET volume with MR T2WI volume is no statistical significance.

Key words

Cervix neoplasms / Positron-emission tomography / Magnetic resonance imaging

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LU Yue-yue, SUN Hong-zan, MA Quan-mei, XIN Jun. The consistency investigation of PET volume and MR volume for the cervical cancer using 18F-FDG PET/MR[J]. Journal of China Clinic Medical Imaging. 2018, 29(2): 112-117

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