目的：探讨mono、bi两种拟合方法测得体素内不相干运动（Intravoxel incoherent motion，IVIM）参数的差异及在鉴别乳腺良恶性病变中的诊断价值。方法：分析54例患者共58个乳腺病灶，其中良性病灶27个，恶性病灶31个，应用IVIM后处理软件测量mono、bi两种拟合方法测得D值、D*值及f值；应用SPSS 22.0统计软件比较mono、bi两种拟合方法测得乳腺良恶性病变各参数CV大小；比较mono、bi两种拟合方法测得乳腺良恶性病变IVIM参数的差异及鉴别乳腺良恶性病变的诊断效能。结果：mono拟合方法测得良恶性病变的IVIM参数CV小于bi；mono、bi两种拟合方法测得乳腺良恶性病变IVIM参数D值及D*值均具有统计学差异，f值没有统计学差异；乳腺良恶性病变通过mono拟合方法获得IVIM参数D及D*值具有统计学差异，bi拟合方法仅有D值存在统计学差异；在鉴别乳腺良恶性方面，mono拟合方法测得D值曲线下面积大于bi拟合方法。结论：乳腺病变mono拟合方法测得IVIM参数优于bi拟合方法，mono拟合方法更加适合乳腺病变IVIM参数测量。
Abstract
Objective: To investigate the difference of parameters from mono and bi based intravoxel incoherent motion(IVIM)-deprived algorithm in breast lesions, and the value in differential diagnosis of benign and malignant breast lesions. Methods: IVIM-MR parameters from a total of 58 breast lesions(27 benign and 31 malignant lesions) were taken from 54 female, including D value, D* value and f value generated and measured by two fitting methods. SPSS 22.0 statistical software was used to compare the coefficient of variation of the parameters measured by two fitting methods, and investigated the difference between mono and bi based IVIM fitting methods. The diagnostic performance in differentiating benign and malignant breast lesions was also compared between mono and bi fitting methods. Results: The coefficient of variation of IVIM parameters by mono fitting method was less than bi from breast lesions. There were significant differences for D and D* values between mono and bi in breast lesions, but the f value was not. The values of D and D* were statistically different by mono fitting method in benign and malignant breast lesions, and the D values on bi fitting method was also so. The area under curve for D value measured by mono fitting method was larger than bi in differentiating benign and malignant breast lesions. Conclusion: Compared with the bi fitting method, mono fitting method is more valuable for the differential diagnosis of benign and malignant breast lesions, and is more suitable for IVIM parameter measurement of breast lesions.
关键词
乳腺疾病 /
磁共振成像
Key words
Breast diseases /
Magnetic resonance imaging
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基金
本研究受甘肃省自然科学基金项目（编号1606RJZA160）资助。
