摘要
目的:通过离体肝脏射频消融(RFA)实验,评价高渗盐水、冰醋酸以及冰醋酸和高渗盐水混合溶液(AAHS)对RFA的增效作用。方法:取厚度和大小近似的新鲜猪肝12块,每3块肝脏作为一组进行射频消融实验。A组:单纯RFA,B组:36% NaCl+RFA,C组:50%冰醋酸+RFA,D组:50%冰醋酸+36% NaCl+RFA。每组猪肝上选取12个点,每个点注射1ml上述试剂后即进行射频消融。记录最低阻抗、消融持续时间并测量消融区的深径及横径,进行统计学分析。结果:A组最低阻抗值最高,同其它组最低阻抗间具有显著差别;B、D组最低阻抗值明显低于A、C组;B、D组间的差别不具有统计学意义。各组射频消融持续的时间也存在差别,其中A组消融持续时间最短,B组持续时间最长。各组消融区最大面积的平均值中D组的面积值最大,A组消融最大切面的面积最小,B组的消融最大切面面积仅次于D组,两者具有显著差别,B组同其它组亦具有显著差别。结论:将射频消融同50% AAHS溶液注射联合比单纯射频消融能获得更大的射频毁损区,其对肝脏射频消融的增效作用大于单一溶液的作用。
Abstract
Objective: To compare the effects of hypertonic saline, acetic acid and acetic acid-hypertonic saline solution (AAHS)-enhanced hepatic radiofrequency and to determine the optimal solution in order to maximize its effect on the extent of the RFA-induced coagulation necrosis. Material and Methods: Tweleve pieces of fresh ex vivo pork liver were assigned to one of the four groups: group A: RFA alone; group B: RFA with 36% NaCl injection; group C: RFA with 50% acetic acid injection; group D: RFA with 50% AAHS. A volume of 1ml various solution were injected into the liver respectively before RFA. Twelve lesions were obtained in each group of liver. The lowest impedance value and persistent time were recorded. Then the long and transverse diameter of the necrotic lesion were measured, the areas of radiofrequency induced coagulation were calculated. Finally, the values were evaluated statistically. Results: The lowest impedance in group A is the highest. The lowest impedance value in group A were compared with other groups, the difference was statistically significant. However, compared the lowest impedance value in group B with that in group C, there was no significant difference. Radiofrequency enery persistent time in group A was significantly shorter than those in group B, C or D(P<0.05). Radiofrequency persistent time in group B was the longest, compared group B with other groups, the difference was significant. Coagulation necrosis areas in group D was maximum, compared group D with other groups, the differences were statistically significant(P<0.05). Conclusion: Combined 50% AAHS injection and RFA can increase the dimension of coagulation necrosis in the ex vivo pork liver.
关键词
胃肠病学 /
导管消融术 /
指示剂和试剂
Key words
gastroenterology /
catheter ablation /
indicators and reagents
蒋宝国;徐 克;何东风.
不同辅助性试剂对肝脏射频消融增效作用的实验研究[J]. 中国临床医学影像杂志. 2006, 17(1): 21-23
JIANG Bao-guo;XU Ke;HE Dong-feng.
An experimental study of the enhanced effect of radiofrequency ablation with adjuvant agent[J]. Journal of China Clinic Medical Imaging. 2006, 17(1): 21-23
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