摘要
目的:探讨肝内胆管癌(IHCC)螺旋CT(SCT)表现特征与血管内皮生长因子(VEGF)的表达水平及微血管密度(MVD)的关系。材料和方法:对经手术病理证实的24例IHCC患者共28个病灶,观察其SCT表现特征,用免疫组化SP法检测肿瘤VEGF的表达水平,用CD34标记微血管染色,进行MVD计数。对肿瘤的SCT表现特征与其VEGF表达、MVD进行统计学对照分析。结果:IHCC的VEGF表达与MVD呈正相关(r=0.46),SCT图像上显示的肿瘤大小、侵袭转移性与VEGF存在相关性(P均<0.05),肿瘤大小、侵袭转移性、肿瘤边界、胆管扩张及延迟强化形式与MVD相关(P均<0.05)。结论:IHCC的SCT表现特征在一定程度上能反映VEGF的表达以及肿瘤微血管生成情况,有助于IHCC的早期诊断及治疗方案的选择。
Abstract
Objective: To investigate the correlation between characteristic features of spiral computed tomography(SCT) and the expression of vascular endothelial growth factor(VEGF) and microvessel density(MVD) in intrahepatic cholangiocarcinoma(IHCC). Methods: Triple-phase SCT scanning was performed in 24 patients with 28 pathological confirmed IHCC lesions. SCT signs were observed. Immunohistochemical analysis was carried out in 28 lesions to examine the expression of VEGF and quantity MVD by using antibodies against CD34 in IHCC. The features of SCT were compared with all immunohistochemical results of IHCC. Results: Size of the lesions, invasion and metastasis of IHCC on CT scanning correlated with the expression of VEGF(P<0.05); tumor edge, size of the lesions, invasion and metastatic bile duct dilation and delayed enhancement pattern of IHCC correlated with MVD(P<0.05). Conclusion: SCT imaging features could reflect tumor angiogenesis in certain extent and infer the expression of VEGF, which is very helpful for its early diagnosis and the selection of proper therapy.
关键词
胆管肿瘤 /
体层摄影术 /
螺旋计算机 /
血管内皮生长因子类
Key words
bile duct neoplasms /
tomography /
spiral computed /
vascular endothelial growth factors
乔慧洁;王 滨;宋修峰;于德新;周茂义;李丽新.
肝内胆管癌SCT表现特征与VEGF表达、MVD的相关性研究[J]. 中国临床医学影像杂志. 2006, 17(1): 24-27
QIAO Hui-jie;WANG Bin;SONG Xiu-feng;YU De-xin;ZHOU Mao-yi;LI Li-xin.
Correlation between spiral CT imaging features with the expression ofVEGF and MVD in intrahepatic cholangiocarcinoma[J]. Journal of China Clinic Medical Imaging. 2006, 17(1): 24-27
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