摘要
目的:探讨大脑各部位平均表观弥散系数(ADC)值与年龄、性别的关系。材料和方法:选择健康男女各30名,分为3个年龄组:20~34岁,35~49岁,50~64岁,每组20人。所有对象进行MRI检查,包括常规MRI和EPI弥散加权成像,弥散敏感系数分别为b=0,b=1000s?蛐mm2。测定双侧脑组织的34个感兴趣区的平均ADC值。结果:①灰质的平均ADCAV表现随年龄增加的线形下降趋势,白质、丘脑、基底节、侧脑室的平均ADCAV都表现随年龄增加的线形增加趋势。②男性灰质的平均ADCAV为[0.81±0.05(0.68~0.92)]×10-3mm2/s,女性灰质的平均ADCAV为[0.78±0.05(0.71~0.91)]×10-3mm2/s,二者间存在差异。③侧脑室CSF的平均ADCAV与年龄和性别间存在交互作用,其它部位间无交互作用存在。结论:正常人脑各部位ADC值的研究为弥散成像进一步临床应用和脑老化研究提供了很好的依据和指导。
Abstract
Objective: To determine whether the mean ADC values in various regions of the brain differ with age and sex. Materials and Methods: Thirty healthy men and 30 healthy women were included, and divided into 3 groups according to age. In group 1 the age were 20~34 years old, group 2 35~49 years old, and group 3 50~64 years old(n=20 each). All subjects were examined with MR imaging, including conventional and EPI diffusion-weighted imaging with two b values(0 and 1000mm2/s). Bilateral ADCAV values were determined in 34 regions of interest encompassing the entire brain. Results: ①The mean ADCAV values in the cortical gray matter showed a descent tendency with advancing age; an increased tendency were showed in the mean ADCAV values of the white matter and thalami, basal ganglia, the lateral ventricle. ②A difference in the mean ADCAV values of the cortical gray matter were observed between men and women, the value in men was[0.81±0.05(0.68~0.92)]×10-3mm2/s, and the value in women was [0.78±0.05(0.71~0.91)]×10-3mm2/s. ③The mean ADCAV values of CSF in the lateral ventricle had interaction between age and sex, no interaction were showed in the others parts. Conclusions: The study of ADCAV values in normal human brains can be used for reference and instruction in future clinical studies and normal brain aging.
关键词
脑 /
磁共振成像 /
弥散 /
年龄因素 /
性别因素
Key words
brain /
diffusion magnetic resonance imaging /
age factors /
sex factors
宋建勋;鲁虹霞;何 宁;位春萍;刘建莉.
正常人脑ADC值与年龄、性别的相关性研究[J]. 中国临床医学影像杂志. 2006, 17(1): 4-8
SONG Jian-xun;LU Hong-xia;HE Ning;WEI Chun-ping;LIU Jian-li.
Study of ADC value in normal human brain correlated with age and sex[J]. Journal of China Clinic Medical Imaging. 2006, 17(1): 4-8
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