C-erbB-2、MVD在卵巢肿瘤组织中的表达与CPA血流的关系

金 蓉; 李彦敏; 崔 壮; 焦 彤; 高卫平

中国临床医学影像杂志 ›› 2006, Vol. 17 ›› Issue (10) : 566-568.

论著

C-erbB-2、MVD在卵巢肿瘤组织中的表达与CPA血流的关系

金蓉1,李彦敏1,崔壮2,焦彤1,高卫平2

作者信息 +

C-erbB-2, MVD expression in ovarian tumors and their relationship to the blood flow of CPA

JIN Rong1, LI Yan-min1, CUI Zhuang2, JIAO Tong1, GAO Wei-ping2

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文章历史 +

摘要

目的:探讨卵巢肿瘤组织中C-erbB-2、MVD表达与CPA血流的关系。方法:对50例卵巢肿瘤患者术前应用CPA检测卵巢组织内的血流信号,测其血流阻力指数(RI),术后采用免疫组化法检测该组织中C-erbB-2、MVD的表达。结果:恶性卵巢肿瘤组织中的C-erbB-2的阳性表达率(83.33%)显著高于良性组(30%,P<0.05),其表达强度与CPA血流分级呈正相关(r=0.847,P<0.05)。良、恶性卵巢肿瘤组织中C-erbB-2阳性表达组的MVD(53.37±7.91)显著高于阴性表达组(38.93±3.19,P<0.05)。卵巢恶性肿瘤组织的MVD(48.84±6.19)显著高于良性组(20.90±2.71,P<0.05),其MVD与CPA的血流分级呈正相关(r=0.823,P<0.05)。恶性卵巢肿瘤的RI值(0.36±0.06)显著低于良性组(0.68±0.07,P<0.05),其RI值与MVD呈负相关(r=-0.806,P<0.05)。结论:巢卵肿瘤组织中C-erbB-2、MVD的表达为临床应用CPA提供了可靠的病理学基础,而CPA则为临床鉴别良、恶性卵巢肿瘤提供了敏感的血流信息。

Abstract

Objective: To evaluate the relationship between C-erbB-2, MVD expressions in ovarian tumors and the blood flow of CPA. Methods: Fifty cases of ovarian tumors were examined preoperatively by CPA whereas C-erbB-2 and MVD were stained with immunohistochemistry after operation. Results: The positive expression rate of C-erbB-2 in malignant ovarian tumors was 83.33% which was higher than that in the benign group(30%, P<0.05), the MVD value of malignant ovarian tumors showed positive correlation to the degree of CPA(r=0.823, P<0.05), the MVD value(53.37±7.91) in the positive C-erbB-2 groups including benign and malignant ovarian tumors was higher than that in negative C-erbB-2 group(38.93±3.19, P<0.05). MVD in the malignant ovarian tumors(48.84±6.19) was higher than that in the benign group(20.90±2.71, P<0.05). Their MVD demonstrated a positive correlation to the degree of CPA. The RI value of malignant group(0.36±0.06) was significantly lower than that of the benign group(0.68±0.07, P<0.05). RI values and MVD showed negative correlation(r=-0.806, P<0.05). Conclusion: The expressions of C-erbB-2 and MVD for ovarian tumors support CPA pathologically and the latter provides in turn the sensitive blood flow information for diagnosis of benign and malignant ovarian tumors in clinic.

导出引用

金蓉;李彦敏;崔壮;焦彤;高卫平. C-erbB-2、MVD在卵巢肿瘤组织中的表达与CPA血流的关系[J]. 中国临床医学影像杂志. 2006, 17(10): 566-568

JIN Rong;LI Yan-min;CUI Zhuang;JIAO Tong;GAO Wei-ping. C-erbB-2, MVD expression in ovarian tumors and their relationship to the blood flow of CPA[J]. Journal of China Clinic Medical Imaging. 2006, 17(10): 566-568

中图分类号： R737.31 R445.1