摘要
目的:研究乳腺癌99mTc-HL91乏氧显像以及与乏氧诱导因子-1α(HIF-1α)表达水平的相关性。方法:31例乳腺癌患者行SPECT 99mTc-HL91乏氧显像,利用计算机感兴趣区(ROI)技术计算乳腺癌病灶计数/对侧计数(T/TN值),免疫组化方法检测肿瘤组织HIF-1α表达水平。结果:31个病灶对99mTc-HL91的摄取均高于对侧正常乳腺组织,99mTc-HL91摄取程度与肿瘤大小无相关关系(P>0.05);注射99mTc-HL91 4小时后SPECT显像浸润性导管癌T/NT值为2.16±0.38,浸润性小叶癌T/NT值为2.10±0.32,两者无显著性差异(P>0.05);病灶的T/NT值为1.36~6.43(中位值2.95),免疫组化结果显示表达HIF-1α的细胞数为25.6%~78.5%(中位数56.3%),两者之间呈正相关(P<0.01)。结论:乳腺癌组织对乏氧显像剂99mTc-HL91有显著的摄取,摄取值与病理类型及病灶大小无相关性,但与HIF-1α的表达存在正相关。
Abstract
Objective: To study the 99mTc-HL91 hypoxia imaging in breast carcinoma and correlation between 99mTc-HL91 uptake and expression of HIF-1α. Methods: Thirty-one patients with primary breast carcinoma diagnosed by fine needle aspiration were underwent 99mTc-HL91 hypoxia imaging. Regions of interest(ROI) were drawn on the tumor(T) and contralateral normal breast tissue(NT), T/NT ratios were measured for all scans. The expression of HIF-1α was detected by immunohistochemical method. Results: In all the 31 patients, 99mTc-HL91 uptake of tumor tissue was obviously higher than that of normal tissue, and no relevance to the tumor size(P>0.05). Four hours after injecting 99mTc-HL91, the T/TN of infiltrating ductal carcinoma(IDC) and infiltrating lobular carcinoma(ILC) were 2.16±O.38 and 2.10±0.32 respectively(P>0.05?). In all the 31 patients’ T/NT ratio ranged from 1.36 to 6.43(median: 2.95), the percentage of tumor cells expressing HIF-1α was 25.6%~78.5%(median: 56.3%), and a positive correlation was found between them(P<0.01). Conclusion: The tissue of breast carcinoma can uptake 99mTc-HL91 obviously and has no relevance to pathologic type and tumor size, but expresses a positive correlation with HIF-1α.
关键词
乳腺肿瘤 /
放射性核素显像
Key words
breast neoplasms /
radionuclide imaging
宋武战;汪 静;池 君;王喜青;王云雅;王 莹.
乳腺癌99mTc-HL91乏氧显像和HIF-1α表达相关性的实验研究[J]. 中国临床医学影像杂志. 2006, 17(10): 569-571
SONG Wu-zhan;WANG Jing;CHI Jun;WANG Xi-qing;WANG Yun-ya;WANG Ying.
Experimental study of the correlation between 99mTc-HL91 hypoxia imagingand expression of HIF-1α in breast carcinoma[J]. Journal of China Clinic Medical Imaging. 2006, 17(10): 569-571
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