摘要
目的:探讨18F-FDG PET显像对原发性乳腺癌新辅助化疗早期疗效评价的价值。方法:对31例经细针穿刺或针吸细胞活检确诊为原发性乳腺癌的患者在化疗前,化疗第1、3疗程结束后分别行18F-FDG PET显像,根据PET显像结果计算乳腺癌病灶放射性摄取比值(T/N),化疗结束后评价疗效,以WHO制定的肿瘤化疗评价标准分为有效组[R(+),n=22]和无效组[R(-),n=9]。结果:化疗前R(+)组和R(-)组T/N比值分别为3.18±0.41、3.14±0.52(P>0.05),化疗第1、3疗程后R(+)组T/N比值从3.18±0.41分别降低为2.62±0.38、2.06±0.45(P<0.05),而R(-)组T/N比值从3.14±0.52分别降低为3.01±0.47、2.87±0.27(P>0.05);R(+)组T/N比值降低的百分率第1、3疗程后分别为16.12%±7%、33.42%±6%(P<0.05),R(-)组分别为4.09%±3%、8.89%±6%(P>0.05),R(+)组降低的百分率明显高于R(-)组(P<0.05)。若以第1疗程结束后T/N比值降低百分率≥10%作为监测治疗有无反应的阈值,18F-FDG PET评价疗效的灵敏度、特异性分别为90%、100%。结论:18F-FDG PET显像对乳腺癌新辅助化疗早期疗效的评价具有一定的临床价值。
Abstract
Objective: To evaluate the response to neo-adjuvant chemotherapy of patients with primary breast cancer in early stage using 18F-FDG PET imaging. Method: 18F-FDG PET tomography fusion imaging were performed on 31 patients with primary breast cancer at pre-chemotherapy, after the first and the third course of treatment. Tumor-to-normal tissue background(T/N) ratios were measured for all scans, all patients were diagnosed by fine-needle aspiration(FNA) cytology. According to the evaluation criterion of WHO for tumor chemotherapy curative effect, all patients were divided into two groups, responders[R(+), n=22] and non-responders[R(-), n=9]. Results: Before chemotherapy, the T/N value of R(+) and R(-) group were 3.18±0.41 and 3.14±0.52(P>0.05) respectively. After the first and the third course of treatment, the T/N value of R(+) group decreased significantly from 3.18±0.41 to 2.62±0.38 and 2.06±0.45(P<0.05) respectively. However in the R(-) group T/N value decreased slightly from 3.14±0.52 to 3.01±0.47 and 2.87±0.27(P>0.05). The decrease percentage of T/N in R(+) group after the first and the third course of treatment were significantly higher than those in the R(-) group, being 16.12%±7% and 33.42%±6%, 4.09%±3%(P<0.05) and 8.89%±6%(P<0.01) respectively. In the R(+) group, the decrease percentage in T/N after the first and the third course treatment had significant difference?穴16.12%±7% and 33.42%±6%, P<0.05), but in R(-) group there were no significant difference(P>0.05). Using a decrease of T/N value≥10% as a threshold for monitoring the treatment response at the end of the first course of treatment, 18F-FDG PET imaging had a sensitivity of 90% and a specificity of 100%. Conclusions: The results suggested that 18F-FDG PET imaging had a certain clinical value to evaluate the chemotherapy response in primary breast cancer in early stage.
关键词
乳腺肿瘤 /
正电子发射断层显像术 /
药物疗法
Key words
breast neoplasms /
positron-emission tomography /
drug therapy
宋武战;汪 静;池 君;王喜青;王云雅;王 莹;张子泰.
18F-FDG PET显像对原发性乳腺癌新辅助化疗反应的监测[J]. 中国临床医学影像杂志. 2006, 17(2): 71-72
SONG Wu-zhan;WANG Jing;CHI Jun;WANG Xi-qing;WANG Yun-ya;WANG Ying;ZHANG Zi-tai.
Monitoring the chemotherapy response in primary breast cancer using 18F-FDG PET[J]. Journal of China Clinic Medical Imaging. 2006, 17(2): 71-72
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