摘要
目的:改进微波消融技术以扩大肝组织凝固范围,为临床改善局部疗效提供实验依据。方法:采用一种新型的水冷式低杆温微波电极对离体新鲜猪肝行微波消融,单次能量输出60~90W,5~25min,观察不同消融条件造成的组织凝固范围和形态。结果:单次能量输出造成的组织消融范围为(4.5~8.3)cm×(3.0~6.1)cm。单纯增加输出功率时,凝固灶以纵径增长为主,只有同时延长消融时间才可获得纵横径的显著增大,70~80W,25min最接近类圆形,是比较满意的消融条件。结论:加大微波的输出功率和延长消融时间可以显著扩大肝组织凝固范围,结合使用低杆温电极,临床治疗肝癌时可望改善局部疗效。
Abstract
Objective: To expand coagulation zone in liver tissue by improving microwave ablation technique, so as to provide experimental evidence for clinical improvement of local efficacy. Methods: A novel microwave antenna with water-cooled shaft was used in fresh liver of pig in vitro. Microwave energy was applied in one session at 60~90W for 5~25min, and the diameter and appearances of coagulation were observed. Results: Coagulation diameters were (4.5~8.3)cm×(3.0~6.1)cm. Elevation of energy power alone resulted in significant increase of longitudinal diameter, while both longitudinal and transverse diameters were significantly increased when accompanied with prolongation of ablation time. 70~80W, 25min produced the best coagulation appearances and was considered as appropriate ablation parameters for clinical use. Conclusions: By using water-cooled microwave antenna, coagulation zones in the liver tissue were significantly expanded with increase of energy power and prolongation of ablation time, which may help to improve local efficacy of image-guided liver cancer ablation.
关键词
肝 /
微波
Key words
liver /
microwaves
匡 铭;吕明德;谢晓燕;徐辉雄;刘广健;徐作峰;郑艳玲;梁瑾瑜.
运用低杆温微波电极扩大肝脏消融范围的实验研究[J]. 中国临床医学影像杂志. 2006, 17(2): 85-87
KUANG Ming;LV Ming-de;XIE Xiao-yan;XU Hui-xiong;LIU Guang-jian;XU Zuo-feng;ZHENG Yan-ling;LIANG Jin-yu.
Water-cooled microwave antenna for expanding ablation zone: in vitro porcine liver experiment[J]. Journal of China Clinic Medical Imaging. 2006, 17(2): 85-87
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