SA-DTPA-Gd经腹腔和静脉给药后荷人结肠癌裸鼠的MR增强对比研究

叶靖; 许乙凯; 刘岘; 陆雪松; 许鹏君; 黄其鎏; 蒋志强; 吕国士

中国临床医学影像杂志 ›› 2006, Vol. 17 ›› Issue (3) : 167-170.

论著

SA-DTPA-Gd经腹腔和静脉给药后荷人结肠癌裸鼠的MR增强对比研究

叶靖1,许乙凯1,刘岘2,陆雪松1,许鹏君1,黄其鎏1,蒋志强1,吕国士1

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Comparative studies on MR enhancement of SA-DTPA-Gd after different routes of administration in nude mice bearing human colon carcinoma

YE Jing1, XU Yi-kai1, LIU Xian2, LU Xue-song1, XU Peng-jun1, HUANG Qi-liu1, JIANG Zhi-qiang1, LV Guo-shi1

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摘要

目的:探讨不同的给药途径对MR预定位免疫成像靶瘤性致增强作用的影响。方法:2组荷人结肠癌细胞裸鼠分别经腹腔和静脉注射SA-DTPA-Gd,检测各组肿瘤组织和肝组织的信号强度。结果:肿瘤在静脉给药后6h强化率达到最高(70.2%),而腹腔组中9h肿瘤的强化率最高(46.4%),两者之间具有显著差异;肝组织在腹腔组中峰值强化率为23.7%,而静脉组中最高为20.4%,两者之间差异不显著。结论:静脉给药更有利于肿瘤的SA-DTPA-Gd摄取并具有更为均匀的瘤内分布。

Abstract

Objective: To investigate MR enhancement of different administration routes in MR pretargeting immunology imaging. Methods: Two groups of mice were injected with SA-DTPA-Gd through tail vein(iv) and intra-peritoneal cavity(ip) respectively, and the MR signal intensity of tumor and liver was determined. Result: In iv group and ip group the maximum enhancement rate of tumor was 70.2% and 46.4% respectively, and there was significant difference. The maximum enhancement rate of liver was 23.7% in ip group and 20.4% in iv group, and there was no signifinant difference. Conclusion: Intravenous injection is in favor of SA-DTPA-Gd’s accumlation in tumor than intraperitoneal injection, and a more homogenious intratumoral distribution is archived.

导出引用

叶靖;许乙凯;刘岘;陆雪松;许鹏君;黄其鎏;蒋志强;吕国士. SA-DTPA-Gd经腹腔和静脉给药后荷人结肠癌裸鼠的MR增强对比研究[J]. 中国临床医学影像杂志. 2006, 17(3): 167-170

YE Jing;XU Yi-kai;LIU Xian;LU Xue-song;XU Peng-jun;HUANG Qi-liu;JIANG Zhi-qiang;LV Guo-shi. Comparative studies on MR enhancement of SA-DTPA-Gd after different routes of administration in nude mice bearing human colon carcinoma[J]. Journal of China Clinic Medical Imaging. 2006, 17(3): 167-170

中图分类号： R735.35 R445.2