摘要
目的:评价腺苷试验201Tl心肌灌注显像的不良反应及对冠心病的诊断价值。方法:21例临床疑诊冠心病患者,按恒定速度静脉注射腺苷(0.14mg/min·kg)。在开始注射腺苷后第3分钟末静脉注射201Tl 1.295×108Bq,至开始注射腺苷后第6分钟末停止腺苷注入。休息2分钟后采集负荷相;2~4小时后采集再分布影像。所有患者同期(2周内)均行冠状动脉造影术。结果:腺苷试验201Tl心肌灌注显像对冠心病的诊断敏感性、特异性、阳性预测率、阴性预测率、准确性分别为92.86%,57.14%,81.25%,80.0%,80.95%。对单支、双支、三支冠脉病变患者的诊断阳性率分别为83.33%,100%,100%,总体诊断阳性率为92.86%。结论:腺苷试验201Tl心肌灌注显像不良反应轻微,是一种安全可靠、有效的冠心病诊断方法,具有较高的敏感性和准确性。
Abstract
Objective: The aims of this study were to evaluate the side effect and diagnostic value of adenosine 201Tl myocardial perfusion imaging for detecting coronary artery disease(CAD). Methods: A total of 21 patients with suspected CAD were submitted with adenosine stress myocardial perfusion imaging. Adenosine was injected by minipump(140 microgram per kg body weight per minute). The total time of adenosine infusion was 6 minutes. At the third minute of adenosine infusion, a bolus of 1.295×108Bq thallium-201 was injected, and SPECT acquisition of burden imaging was obtained at 2 minutes after completion of adenosine infusion. After 2~4 hours redistribution imaging was obtained. Coronary angiography (CAG) was performed in all patients within 2 weeks. Results: In adenosine stress myocardial perfusion imaging, the sensitivity, specificity, positive predictive value, negative predictive value, accuracy were 92.86%, 57.14%, 81.25%, 80.0%, 80.95% respectively. The positive diagnostic rate of single, two and three branches lesions were 83.33%, 100% and 100% respectively. Total positive diagnostic rate was 92.86%. Conclusion: Domestic adenosine stress myocardial perfusion imaging is a safe and reliable diagnostic method for CAD. It has mild side effects, high sensitivity and accuracy in CAD diagnosis.
关键词
冠状动脉疾病 /
放射性核素显像 /
腺苷
Key words
coronary disease /
radionuclide imaging /
adenosine
陈贵兵;蒋宁一;刘 生;卢献平;梁九根;张 弘;吴 华.
腺苷试验201Tl心肌灌注显像不良反应及对冠心病诊断价值的初步临床研究[J]. 中国临床医学影像杂志. 2006, 17(7): 372-375
CHEN Gui-bing;JIANG Ning-yi;LIU Sheng;LU Xian-ping;LIANG Jiu-gen;ZHANG Hong;WU Hua.
Preliminary clinical study in side effect and diagnostic value of adenosine 201Tl myocardial perfusion imaging for detecting coronary artery disease[J]. Journal of China Clinic Medical Imaging. 2006, 17(7): 372-375
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