摘要
目的:分析18F-FDG PET显像在临床寻找“不明原因发热”原因的应用价值。方法:24例符合“不明原因发热”诊断标准的住院病人,进行18F-FDG PET全身显像,结果提供给临床,帮助作病因诊断。结果:24例病人可分为3种情况:①18F-FDG PET显像阴性或不能提供临床诊断有效信息;②显像结果提供了有效信息,帮助临床诊断;③18F-FDG PET显像高度怀疑为恶性病灶。18F-FDG PET显像有助于临床诊断“不明原因发热”病因的阳性率可达58.3%(14/24),其中明确为恶性病变的占71.4%(10/14),包括淋巴瘤3例?熏 白血病2例。良性病变28.6%(4/14),以感染和炎症为主。结论:18F-FDG PET显像有助于临床诊断“不明原因发热”的诊断。
Abstract
Objective: To assess the clinical value of 18F-FDG PET imaging in diagnosing fever of unknown origin(FUO). Methods: Twenty-four in-patients diagnosed as FUO were enrolled in this study. They met the diagnostic criteria of FUO as fever higher than 38.3°C documented on several occasions and persisting without diagnosis for at least 3 weeks in spite of investigation for at least 1 week. Whole body 18F-FDG PET was performed in these patients. Final diagnosis was made when patients were discharged. Results: Twenty-four patients were divided into three groups according to the results of their 18F-FDG PET imaging and the final diagnosis.①18F-FDG PET imaging from 10 cases can’t provide useful information to clinical diagnosis. These included 8 cases of negative 18F-FDG PET imaging. Among them, 1 case was diagnosed as collagen disease, 1 was vascular disease, 2 cases were disease of connective tissue and another 4 cases had no final diagnosis. 2 cases had positive imaging results but without clinical specificity, including 1 case with high metabolism in bilateral hilar regions and another one with uniform hyperplasia in bone marrow. Neither of them had final diagnosis; ②four cases got useful clinical information from 18F-FDG PET imaging. These included hyper-metabolism lesions in bone marrow, detection of lymph nodes in neck and local hyper-metabolic lesions in liver. Final diagnosis were hepatic hemangioma with infection, myelodysplastic syndrome, myeloid leukemia, respectively; ③ten cases were strongly suspected as malignant diseases, including 1 case of colon leiomyosarcoma, 1 case of colon cancer and 1 case of nasopharyngeal cancer. 2 cases with multiple bone metastatic lesions with unknown origin. Five cases had remarkable F-FDG uptake in abdomen, among them, 3 cases were diagnosed as lymphoma and confirmed by pathology, 1 case was lymphadenitis and another case had inflammation of gallbladder fossa. Conclusion: 18F-FDG PET imaging can make contribution to clinical diagnosis of FUO. The sensitivity was 58.3%(14/24). Among them, malignant disease was as high as 71.4%(10/14) due to the case number of hematological malignant disease in the studied cohort.
关键词
发热 /
原因不明 /
正电子发射断层摄影术
Key words
fever of unknown origin /
position-emission tomography
李培勇;江旭峰;张立颖;管 梁;陈素芸;姜 磊;瞿毓敏;朱承谟.
18F-FDG PET在探查临床“不明原因发热”中的应用[J]. 中国临床医学影像杂志. 2006, 17(8): 461-463
LI Pei-yong;JIANG Xu-feng;ZHANG Li-ying;GUAN Liang;CHEN Su-yun;JIANG Lei;QU Yu-min; ZHU Cheng-mo.
Application of 18F-FDG PET study in FUO patients[J]. Journal of China Clinic Medical Imaging. 2006, 17(8): 461-463
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
