MR弥散加权成像在脑胶质瘤中的应用价值

王巍; 刘志兰; 刘鹏飞

中国临床医学影像杂志 ›› 2007, Vol. 18 ›› Issue (1) : 8-9.

论著

MR弥散加权成像在脑胶质瘤中的应用价值

王巍，刘志兰，刘鹏飞

作者信息 +

The application of diffusion weighted imaging in gliomas

WANG Wei, LIU Zhi-lan, LIU Peng-fei

Author information +

文章历史 +

摘要

目的：探讨磁共振弥散加权成像（DWI）及表观弥散系数（ADC）图在鉴别胶质瘤实质部分、瘤周水肿及正常组织中的应用，及其在胶质瘤良、恶性分级诊断中的价值。方法：采用Philips 1.5T Intera超导型磁共振成像系统，对39例胶质瘤患者均行常规MRI及弥散加权成像。在x，y，z轴3个方向施加弥散梯度。弥散系数（b值）：b=0s/mm2及b=1000s/mm2，测量了肿瘤实质部分、瘤周水肿及正常组织的ADC值。结果：脑肿瘤实质部分的DWI和ADC图信号分别高于和低于正常脑组织。肿瘤实质部分的ADC值（1.72±0.78）×10-3（mm2/ｓ）及瘤周水肿的ADC值（1.44±0.31）×10-3（mm2/ｓ）与正常组织的ADC值（0.93±0.59）×10-3（mm2/ｓ）相比均有显著差异（P<0.01），肿瘤组织与瘤周水肿之间无显著差异（P>0.05）；1~2级低度胶质瘤的平均ADC值高于3~4级恶性胶质瘤的平均ADC值（P<0.05）。结论：DWI、ADC图及ADC值的测量能够用于胶质瘤的肿瘤实质及瘤周水肿与正常脑组织的区分，但不能可靠地鉴别肿瘤组织及瘤周水肿。ADC值能够反映肿瘤的细胞构成，MR弥散加权成像对于良、恶性胶质瘤的分级有较高的预测价值。

Abstract

Objective: To evaluate the usefulness of ADC in differentiating tumor, edema, and normal brain tissue, and in grading the malignancy of cerebral gliomas. Materials and Methods: Using a Philips 1.5T super conduct MR unit, 39 gliomas underwent conventional MR imaging and diffusion weighted imaging. The apparent diffusion coefficients of regions of interest(ROI) were measured with two different b values(b=0s/mm2 and b=1000s/mm2) ADC maps were calculated and ROIs were manually placed over areas of tumor, edema, and normal brain tissue. Results: When ADC values were analyzed as a group, significant differences were found between tumor(1.72±0.78)×10-3(mm2/ｓ), edema(1.44±0.31)×10-3(mm2/ｓ), and normal brain tissues (0.93±0.59)×10-3(mm2/ｓ); but not between tumor and adjacent edema. ADC value of low grade (grade1~2) gliomas is higher than that of high grade(grade3~4) glioma. Conclusion: ADC values helped to distinguish tumor from normal tissue but could not be used to separate tumor and adjacent edema. Individually, ADC values overlapped considerably. The ADC value can reflect cellularity of gliomas, so DWI may predict the degree of malignancy of gliomas.

导出引用

王巍;刘志兰;刘鹏飞. MR弥散加权成像在脑胶质瘤中的应用价值[J]. 中国临床医学影像杂志. 2007, 18(1): 8-9

WANG Wei;LIU Zhi-lan;LIU Peng-fei. The application of diffusion weighted imaging in gliomas[J]. Journal of China Clinic Medical Imaging. 2007, 18(1): 8-9

中图分类号： Ｒ739.41 Ｒ445.2