摘要
目的：评价18F-脱氧葡萄糖（18F-FDG）PET/CT显像、CT在乳腺癌术后复发和转移诊断中的应用价值。方法：37例临床疑乳腺癌术后复发的患者行18F-FDG PET/CT全身显像。图像分析采用视觉和半定量方法（标准摄取值，SUV）分析肿瘤病灶摄取FDG的程度，并参考近期病理检查及CT结果。结果：27例复发患者经组织病理学、活检或细胞学检查和临床随访证实有局部转移，PET/CT显像和CT检查灵敏度分别为96.30%，62.96%，PET/CT显像和CT检查的灵敏度的差异有显著性（χ2=9.247，P<0.05）。14例患者行PET/CT双时相检查，乳腺癌术后患者确诊为转移的9例患者，SUV值均有不同程度增高。结论：18F-FDG PET/CT显像对于乳腺癌术后复发和转移病灶的定性、定位准确性更高，优于CT，是一种有效的诊断方法。
Abstract
Objective: To evaluate the use of 18F-fluorodeoxyglucose(FDG) PET/CT in recurrence and metastasis of breast cancer. Methods: Thirty-seven patients after operation underwent 18F-FDG PET/CT whole body imaging for evaluation of recurrent breast cancer and metastasis. Visual and semiquantitative methods(standard uptake value, SUV) were used to analyze the images. The results of PET/CT imaging were compared with those of pathology or CT. Results: Twenty-seven malignant recurrent breast lesions in thirty-seven resected breast cancers detected by this modality were proven histopathology, biopsy, cytological examination, and clinical follow-up. Among the twenty-seven malignant breast lesions, the diagnostic sensitivity of PET/CT and CT imaging were 96.30% and 62.96% respectively. There were statistical differences in sensitivity between PET/CT and CT(χ2=9.247, P<0.05). Fourteen patients with breast cancer underwent PET/CT at 2 time points. Recurrence and metastasis were diagnosed in 9 patients, and all of their SUVs increased at time 2. Conclusions: 18F-FDG PET/CT makes the location and characterization of the lesions more accurate, and it is a useful diagnostic modality in the diagnosis of recurrent and metastatic breast cancer.
关键词
乳腺肿瘤 /
正电子发射断层显像术 /
体层摄影术 /
X线计算机 /
氟脱氧葡萄糖F18
Key words
breast neoplasms /
positron-emission tomography /
tomography /
X-ray computed /
Fluorodeoxyglucose F18
孙 琳;高再荣;张永学;贾 清;吴志坚;常 伟.
18F-FDG PET/CT、CT在乳腺癌治疗疗效评估中的对比研究[J]. 中国临床医学影像杂志. 2007, 18(10): 689-692
SUN Lin;GAO Zai-rong;ZHANG Yong-xue;JIA Qing;WU Zhi-jian;CHANG Wei.
Comparative study of 18F-FDG PET/CT and CT in evaluating curative effect of breast cancer[J]. Journal of China Clinic Medical Imaging. 2007, 18(10): 689-692
中图分类号：
Ｒ737.9
Ｒ814.42
Ｒ817.4
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