超顺磁性氧化铁粒子增强MR成像在脾脏荷VX2肿瘤动物模型的影像学与病理学对照研究

阳红艳; 许乙凯; 吴元魁; 刘文源; 吕国士; 曹国洪

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中国临床医学影像杂志 ›› 2007, Vol. 18 ›› Issue (10) : 710-715.

论著

超顺磁性氧化铁粒子增强MR成像在脾脏荷VX2肿瘤动物模型的影像学与病理学对照研究

阳红艳1，许乙凯2，吴元魁2，刘文源3，吕国士2，曹国洪2

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Correlation study of experimental superparamagnetic iron oxide-enhancedmagnetic resonance imaging of splenic VX2 tumor in rats with pathology

YANG Hong-yan1, XU Yi-kai2, WU Yuan-kui2, LIU Wen-yuan3, LV Guo-shi2, CAO Guo-hong2

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摘要

目的：建立大鼠脾脏VX2肿瘤模型，分析大鼠脾VX2肿瘤超顺磁性氧化铁（SPIO）增强MR图像上信号强度变化与病理学改变之间的关系。探讨SPIO增强MR在大鼠脾脏转移瘤的应用价值。材料和方法：制作8只脾脏荷VX2肿瘤模型鼠，注射SPIO后行MR扫描，扫描序列采用T1WI（450/12ms)和T2WI（4000/128ms）。分析SPIO增强扫描前后MR图像上不同组织的信号特点。结果：SPIO增强T2WI MR图像上正常脾实质信号强度下降百分比（PSIL）为55.04％；脾脏VX2肿瘤PSIL为0.87％，与正常脾实质的信号强度下降程度有显著性差异（P<0.001）。脾VX2肿瘤的CNR较增强前显著提高（P<0.001）。结论：SPIO增强T2WI MR图像上脾脏－肿瘤的对比显著，提高了病灶的检出率，改善了病灶的影像学特征的描述。

Abstract

Objective: To establish a rodent model of VX2 tumor in spleen of rats. To analyze relationship between the change of the signal intensity on superparamagnetic iron oxide(SPIO) enhanced MR images and pathologic change. To discuss the value of SPIO enhanced detection in splenic metastasis in rat. Methods: Eight rodent model of VX2 tumor in spleen was established successfully. The images were obtained before and after administration of superparamagnetic iron oxide. T1-weighted spin-echo(SE) pulse sequence with a repetition time (TR) of 450ms, and echo time(TE) of 12ms(TR/TE=450/12) were performed. The imaging parameters of T2-weighted SE pulse sequence as follows: TR/TE=4000/128. Results: On SPIO enhancement T2WI sequence the SI of splenic parachyma decreased obviously with percentage of signal intensity loss(PSIL) was 55.04%, but the SI of tumor was not evidently change with PSIL was 0.87%. Nevertheless the SNR of normal splenic parenchyma around the lesions had obvious difference(P<0.001) comparatively. The contrast-to-noise(CNR) between VX2 tumor and splenic parenchyma had an evidently difference with before and after admininstration of SPIO(P<0.001). Conclusions: On SPIO enhanced T2WI the contrast degree of lesions increased obviously. Consequently, SPIO-enhanced T2WI MRI scanning can improve the rate of detection and characterization in lesions of spleen.

导出引用

阳红艳;许乙凯;吴元魁;刘文源;吕国士;曹国洪. 超顺磁性氧化铁粒子增强MR成像在脾脏荷VX2肿瘤动物模型的影像学与病理学对照研究[J]. 中国临床医学影像杂志. 2007, 18(10): 710-715

YANG Hong-yan;XU Yi-kai;WU Yuan-kui;LIU Wen-yuan;LV Guo-shi;CAO Guo-hong. Correlation study of experimental superparamagnetic iron oxide-enhancedmagnetic resonance imaging of splenic VX2 tumor in rats with pathology[J]. Journal of China Clinic Medical Imaging. 2007, 18(10): 710-715

中图分类号： Ｒ733.2 Ｒ445.2