摘要
目的：运用动态增强磁共振成像（DCE-MRI）的方法，并结合血液流变学指标评估早期激素性股骨头缺血坏死（AvNFH）模型不同时期的股骨头血流灌注状态，以探讨DCE-MRI在AvNFH早期诊断中的应用价值。方法：25只健康新西兰大白兔，于用药前和用药后2周、4周、6周、8周，以相同方法行常规及DCE-MRI检查，根据股骨头的时间-信号强度曲线计算股骨头DCE-MRI参数。并于用药后的4周、8周取静脉血进行血液流变学指标检测。动物处死后取双侧股骨头制作病理切片，HE染色光镜观察。结果：①反映早期激素性AvNFH血流灌注状态的时间-信号强度曲线的斜率随着时间的延长逐渐减小（P<0.01），相应的骨小梁空虚骨陷窝数逐渐增多（P<0.01）。②与正常组比较，实验组全血黏度（高切、低切）、血浆黏度及红细胞压积均升高，其中低切全血黏度及红细胞压积的升高有显著性（P<0.05）。③动态增强参数SS与低切全血黏度呈负相关，r=-0.65，P<0.05。结论：DCE-MRI可以评估AvNFH的血流灌注状态，对该病的早期诊断具有重要意义。
Abstract
Objective: To evaluate the value of dynamic contrast-enhanced MRI(DCE-MRI) with hemorrheology in the detection of femoral perfusion in the early stage of steroid-induced avascular necrosis of femoral head(AvNFH) model. Methods: Twenty-five rabbits were examined by non-enhanced, DCE-MRI with the same method before treatment and in the second week, fourth week, sixth week and eighth week after steroid treatment. Venous blood was obtained for hemorrheology in the fourth week, eighth week. After rabbits were killed, paraffin section and HE stained specimen of all the femoral heads were made for pathological investigation. Results: ①The steepest slope(SS) of time-signal intensity curve gradually declined with time in the early stage and intensity of perfusion decreased gradually(P<0.01). Correspondingly, the number of empty lacuna increased gradually(P<0.01). ②Compared with normal group, the indexes of experimental group including whole blood(high and low slice) viscosity, viscosity of plasma and packed cell volume elevated, but only the increase of whole blood(low slice) viscosity, packed cell volume were significant(P<0.05). ③The parameter SS of DCE-MRI correlated negatively with whole blood(low slice)(r=-0.65, P<0.05). Conclusion: DCE-MRI can evaluate the state of blood perfusion of femoral head and is valuable for early diagnosis.
关键词
股骨头坏死 /
磁共振成像
Key words
femur head necrosis /
magnetic resonance imaging
程少容;王仁法;高小玲;杨海涛;冯定义;夏黎明;王承缘.
动态增强MRI评价股骨头血流灌注状态的实验研究[J]. 中国临床医学影像杂志. 2007, 18(2): 110-114
CHENG Shao-rong;WANG Ren-fa;GAO Xiao-ling;YANG Hai-tao;FENG Ding-yi;XIA Li-ming;WANG Cheng-yuan.
Experimental study on dynamic contrast-enhanced MRI in evaluating femoral perfusion[J]. Journal of China Clinic Medical Imaging. 2007, 18(2): 110-114
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