摘要
目的：分析比较99Tcm-甲氧基异丁基异腈（MIBI）双时相断层显像与钼靶X线摄影法对乳腺肿块的临床诊断价值。方法：对93例女性乳腺肿块患者术前1周行99Tcm-MIBI双时相断层和X线钼靶摄影检查，以术后病理结果为金标准，判断以上2种方法在乳腺癌早期诊断中的灵敏性、特异性、准确性、阳性预测值及阴性预测值。结果：①99Tcm-MIBI乳腺双时相断层显像示：良性病变早期和延迟相T/NT比值为2.08±2.85和1.69±3.05，两者有显著性差异（P<0.05）；乳腺癌早期和延迟相T/NT比值为5.00±4.34和6.79±11.94，两者无显著性差异（P>0.05）。②99Tcm-MIBI乳腺肿块双时相断层显像诊断乳腺癌的敏感性为97.1%，特异性为94.8%，准确性为95.7%，阳性预测值为91.9%，阴性预测值为98.2%；X线钼靶诊断乳腺癌的敏感性为82.9%，特异性为70.7%，准确性为75.3%，阳性预测值为63.0%，阴性预测值为87.2%；2种方法对乳腺癌的诊断效能有显著性差异（P<0.05）。结论：99Tcm-MIBI双时相断层显像对乳腺癌的诊断效能优于X线钼靶摄影法。99Tcm-MIBI乳腺双时相断层显像是一种高灵敏性和特异性的乳腺癌检查方法，对鉴别乳腺良恶性病变有较高的临床价值。
Abstract
Objective: To evaluate the value of double-phase 99Tcm-MIBI tomographic imaging and mammography in diagnosis of breast lesions. Methods: Double-phase 99Tcm-MIBI tomographic imaging and mammography were performed within one week for patients with breast neoplasms. The final diagnosis were verified with histological examination. Result: ①The T/NT ratios of early and delayed imaging were 2.08±2.85 and 1.69±3.05 in benign lesions. There was significant difference(P<0.05). The T/NT ratios of early and delayed imaging were 5.00±4.34 and 6.79±11.94 in malignant tumors, there was no significant difference(P>0.05). ②The sensitivity of double-phase 99Tcm-MIBI tomographic imaging in diagnosis of breast cancer was 97.1%; specificity was 94.8%; accuracy was 95.7%; the positive predictive value was 91.9%, and the negative predictive value was 98.2%. The sensitivity of mammography in diagnosis of breast cancer was 82.9% and specificity 70.7% and accuracy 75.3% and the positive predictive value 63.0% and the negative predictive value 87.2%, the two methods showed significant difference(P<0.05). Conclusion: The double-phase 99Tcm-MIBI tomographic imaging is superior to the mammography in diagnosing breast cancer, double-phase 99Tcm-MIBI tomographic imaging has higher sensitivity and specificity in the diagnosis of breast cancer. It is an effective means in differentiating benign from malignant lesions.
关键词
乳腺肿瘤 /
乳房X线摄影术 /
放射性核素显像 /
99m锝甲氧基异丁基异腈
Key words
breast neoplasms /
mammography /
radionuclide imaging /
Technetium Tc 99m sestamibi
陈再君;梁庆模;郑自贵;包 铮;许先华;桂文来;罗茂香.
乳腺肿块99Tcm-MIBI双时相断层显像与X线钼靶对照研究[J]. 中国临床医学影像杂志. 2007, 18(9): 639-642
CHEN Zai-jun;LIANG Qing-mo;ZHENG Zi-gui;BAO Zheng;XU Xian-hua;GUI Wen-lai;LUO Mao-xiang.
Comparative study with double-phase 99Tcm-MIBI tomographic imaging and mammography in diagnosis of breast lesions[J]. Journal of China Clinic Medical Imaging. 2007, 18(9): 639-642
中图分类号：
Ｒ737.9
Ｒ814.41
Ｒ817.4
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