MRI评价bFGF、银杏叶提取物联合应用治疗猫急性脑梗死的实验研究

刘怀军; 贺丹; 吴朔春; 杨桦; 冯平勇; 颜立群

中国临床医学影像杂志 ›› 2008, Vol. 19 ›› Issue (1) : 1-4.

论著

MRI评价bFGF、银杏叶提取物联合应用治疗猫急性脑梗死的实验研究

刘怀军1，贺丹1，吴朔春2，杨桦1，冯平勇1，颜立群1

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MRI evaluation on the treatment of acute cerebral infarction of cat with the combination of bFGF and GbE

LIU Huai-jun1, HE Dan1, WU Shuo-chun2, YANG Hua1, FENG Ping-yong1, YAN Li-qun1

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摘要

目的：利用MR影像学方法对碱性成纤维细胞生长因子（bFGF）、银杏叶提取物（GbE）联合治疗缺血性脑损伤的作用进行评价。方法：40只健康家猫随机平均分为4组。A组（生理盐水对照组），B组（bFGF处理组），C组（GbE处理组），D组（bFGF+GbE处理组）。采用左侧眼眶入路制作大脑中动脉缺血再灌注模型。术后动态进行T1WI、T2WI、FLAIR、DWI序列扫描，并进行神经功能缺损评分。结果：联合治疗组神经功能缺损程度轻，磁共振T1WI、T2WI、FLAIR所见病变程度轻，T2WI显示最终梗死体积小，T2WI-ADC显示梗死周围缺血带转化为梗死的体积小。结论：bFGF、GbE联合治疗猫急性脑梗死优于单一用药组，两者具有协同作用；MRI能客观评价药物疗效，尤其T2WI-ADC异常范围差值是评价药物疗效的重要指标。

Abstract

Objective: To evaluate the therapeutic effect of bFGF and GbE on acute cerebral infarction with MR imaging. Methods: Forty healthy adult cats were equally and randomly devided into 4 groups. All animals were operated to establish the feline models of cerebral focal ischemia-reperfusion by left transorbital approach. They were injected with sodium chloride intravenously for group A, bFGF for group B, GbE for group C and bFGF+GbE for group D. MR scans performed after operation, included T1WI, T2WI, FLAIR, DWI. Philips’s criteria score were evaluated on the cats. Result: The neurological defects score in group D is remarkably lower than that in group B and C. The lesion on T1WI, T2WI, FLAIR, DWI showed more milder. The area of infarct formation were smaller than that in group B and C through the comparison between the ADC images and T2WI images(T2WI-ADC). Conclusion: The treatment results in group D was better than that in group B and C. Both bFGF and GbE can enhance each other’s therapeutic effects. MR imaging could show the therapeutic effect of bFGF and GbE, especially the T2WI-ADC was an important item to evaluate the therapeutic effects.

导出引用

刘怀军;贺丹;吴朔春;杨桦;冯平勇;颜立群. MRI评价bFGF、银杏叶提取物联合应用治疗猫急性脑梗死的实验研究[J]. 中国临床医学影像杂志. 2008, 19(1): 1-4

LIU Huai-jun;HE Dan;WU Shuo-chun;YANG Hua;FENG Ping-yong;YAN Li-qun. MRI evaluation on the treatment of acute cerebral infarction of cat with the combination of bFGF and GbE[J]. Journal of China Clinic Medical Imaging. 2008, 19(1): 1-4

中图分类号： Ｒ743.3 Ｒ445.2