摘要
目的：探讨垂体腺瘤海绵窦侵袭的MRI表现与基质金属蛋白酶诱导因子（EMMPRIN）和Galectin-3表达的相关性。方法：对34例垂体腺瘤患者术前行MRI检查，术后收集标本应用免疫组化SP法检测垂体腺瘤标本中EMMPRIN和Galectin-3表达，分析MRI表现与EMMPRIN和Galectin-3之间的关系。结果：垂体腺瘤海绵窦侵袭的MRI表现中，Knosp评分、Cottier评分、肿瘤形态不规则及双侧海绵窦段颈内动脉不对称性与EMMPRIN和Galectin-3表达有关（P<0.05）。结论：垂体腺瘤海绵窦侵袭MRI特征与EMMPRIN和Galectin-3相关，MRI可对垂体腺瘤海绵窦侵袭程度作出明确诊断。
Abstract
Objective: To investigate the correlation between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer(EMMPRIN) and Galectin-3 in pituitary adenomas. Methods: MRI was performed preoperatively in 34 patients with histologically verified pituitary adenomas, EMMPRIN and Galectin-3 expression were determined by immunohistochemical SP method in all patients. The correlation between expression of determined proteins and MRI features between invasive and non-invasive pituitary adenomas were studied. Results: Among MRI invasive features, Knosp score, Cottier score, irregular tumor shape and bilateral intracavernous carotid artery asymmetry correlated with increased expression of EMMPRIN and Galectin-3(P<0.05). Conclusion: MRI features of cavernous sinus invasion may be related to the expression of EMMPRIN and Galectin-3, MRI is very useful in diagnosing invasive extent of cavernous sinus in pituitary adenomas.
关键词
垂体肿瘤 /
腺瘤 /
基质金属蛋白酶类 /
半乳糖凝集素3 /
磁共振成像
Key words
Pituitary neoplasms /
Adenoma /
Matrix metalloproteinases /
Galectin 3 /
Magnetic resonance imaging
张祎年;何 宁;周俊林.
垂体腺瘤海绵窦侵袭的MRI表现与EMMPRIN和Galectin-3表达的相关性研究[J]. 中国临床医学影像杂志. 2008, 19(1): 10-14
ZHANG Yi-nian;HE Ning;ZHOU Jun-lin.
Correlative study between MRI features of cavernous sinus invasion and expression of extracellular matrix metalloproteinase inducer and Galectin-3 in pituitary adenomas[J]. Journal of China Clinic Medical Imaging. 2008, 19(1): 10-14
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