前列腺癌磁共振波谱成像与弥散成像的对照研究

王锡臻; 王滨; 刘金刚; 牛庆亮; 刘作勤; 刘强

中国临床医学影像杂志 ›› 2008, Vol. 19 ›› Issue (10) : 722-725.

论著

前列腺癌磁共振波谱成像与弥散成像的对照研究

王锡臻^1，2，王滨¹，刘金刚¹，牛庆亮³，刘作勤²，刘强²

作者信息 +

Prostate cancer: a comparison study of 1H-MRSI and DWI

WANG Xi-zhen^{1, 2}, WANG Bin¹, LIU Jin-gang¹, NIU Qing-liang³, LIU Zuo-qin², LIU Qiang²

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文章历史 +

摘要

目的：分析联合应用磁共振波谱成像（MRSI）和弥散成像（DWI）对前列腺癌（PCa）的诊断价值，探讨PCa的（Cho+Cr）/Cit比值与表观扩散系数（ADC）之间的关系。材料与方法：MRI检查使用Siemens Sonata 1.5T高场强超导MR成像仪和腹部相控阵线圈，MRSI序列采用CSI-3D-Prostate序列，采用Spectroscopy软件（Siemens Leonardo工作站）进行波谱数据处理，DWI采用EPI序列。计算PCa（n=38）、良性前列腺增生（BPH）（n=21）及正常外周带（Peripheral zone，PZ）（n=17）3种感兴趣区的（Cho+Cr）/Cit比值及ADC。对比分析（Cho+Cr）/Cit比值与ADC值的相关性。结果：PCa、BPH及PZ的（Cho+Cr）/Cit比值分别为3.98±0.12、0.51±0.19和0.38±0.09，三者代谢比率存在显著差异（P<0.05）。PCa、BPH和PZ的平均ADC值分别为（49.32±12.68）×10-5mm2/s，（86.73±26.75）×10-5mm2/s，（126.25±27.21）×10-5mm2/s，差异有统计学意义（P<0.05）。（Cho+Cr）/Cit比值与Gleason分级存在正相关性（r=0.431，P<0.05），与ADC值存在负相关性（r=-0.309，P<0.05）。结论：PCa组织代谢水平与组织微观结构密切相关，联合应用MRSI和DWI有助于提高PCa的检出率。

Abstract

To analyze the characteristics of prostate cancer(PCa) in 1H-MRSI and DWI; to explore the relationship between(Cho+Cr)/Cit ratio and ADC value. Materials and Methods: The clinical and pathologic information of 38 patients with histologically proven PCa were studied. MR spectroscopic imaging(MRSI) and diffusion weighted imaging(DWI) were performed using a 1.5T superconductive magnet scanner(Siemens Sonata) with a pelvic phased array multi-coil. MRSI was acquired using CSI-3D-Prostate sequence. All of the data was transferred to Siemens Leonardo Workstation. The (Cho+Cr)/Cit ratio of PCa(n=38), benign prostate hyperplasia(BPH)(n=21) and peripheral zone(PZ)(n=17) were calculated by spectroscopy software. DWI was carried out with a modified single-shot SE echo planar imaging(EPI) sequence. Results: The (Cho+Cr)/Cit ratio of PCa, BPH and PZ was 3.98±0.12, 0.51±0.19 and 0.38±0.09(P<0.05), respectively. The ADC value of PCa, BPH and PZ was (49.32±12.68)×10-5mm2/s, (86.73±26.75)×10-5mm2/s and (126.25±27.21)×10-5mm2/s, respectively. The (Cho+Cr)/Cit ratio and ADC value of PCa was different from that of BPH and PZ(P<0.05). (Cho+Cr)/Cit ratio correlated positively with Gleason grade(r=0.431, P<0.05), while negatively with ADC value(r=-0.309, P<0.05). Conclusion: The metabolite ratios relate closely with tissue microstructure. Combined utility of MRSI and DWI can improve the detection of PCa.

导出引用

王锡臻;王滨;刘金刚;牛庆亮;刘作勤;刘强. 前列腺癌磁共振波谱成像与弥散成像的对照研究[J]. 中国临床医学影像杂志. 2008, 19(10): 722-725

WANG Xi-zhen;;WANG Bin;LIU Jin-gang;NIU Qing-liang;LIU Zuo-qin;LIU Qiang. Prostate cancer: a comparison study of 1H-MRSI and DWI[J]. Journal of China Clinic Medical Imaging. 2008, 19(10): 722-725

中图分类号： Ｒ737.25 Ｒ445.2