脑膜瘤磁共振波谱Cho/Cr比值与Ki-67核抗原表达的相关性研究

史瑞华; 翟仁友; 钱晓军; 鲁万红; 顾华

中国临床医学影像杂志 ›› 2008, Vol. 19 ›› Issue (12) : 855-857.

论著

脑膜瘤磁共振波谱Cho/Cr比值与Ki-67核抗原表达的相关性研究

史瑞华，翟仁友，钱晓军，鲁万红，顾华

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Correlation study between Cho/Cr value of MRS and Ki-67 labeling index in meningiomas

SHI Rui-hua, ZHAI Ren-you, QIAN Xiao-jun, LU Wan-hong, GU Hua

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摘要

目的：探讨良、恶性脑膜瘤磁共振波谱（1H-MRS）Cho/Cr比值与Ki-67核抗原表达的相关性。方法：经手术病理证实的36例脑膜瘤在治疗前行常规MRI及1H-MRS检查（脑膜瘤I级30例，II+III级6例）。1H-MRS检查包括PRESS 35、PRESS 144序列。结果：良性脑膜瘤组Cho/Cr比值3.80±1.08；恶性脑膜瘤组为7.22±0.70。差异具有显著性（t=7.40，P=0.000）。良性脑膜瘤组Ki-67积分光密度6.43±1.09；恶性脑膜瘤组为12.15±4.14。相关性分析表明，Ki-67表达与Cho/Cr呈显著正相关（r=0.832，P=0.000）。MRS表现：本组脑膜瘤病例Cho峰升高，Cr降低。结论：脑膜瘤MRS Cho/Cr比值与Ki-67表达具有相关性，是预测肿瘤增殖活性的有价值的指标，有助于脑膜瘤病理分级。

Abstract

Objective: To investigate the correlation between Cho/Cr value of 1H magnetic resonance spectroscopy(1H-MRS) and the Ki-67 labeling index in meningiomas. Methods: Thirty-six patients with meningioma underwent conventional MR and 1H-MRS before operation(Grade I 30 cases; Grade II+III 6 cases). 1H-MRS sequences included PRESS 35, PRESS 144. Expression of Ki-67 nuclear antigen were detected by immunohistochemical method of streptavidin-biotin-peroxidase(SP). Results: The mean Cho/Cr ratio in the benign and malignant groups were 3.80±1.08 and 7.22±0.70, respectively(t=7.40, P=0.000）. Ki-67 in the benign and malignant groups were 6.43±1.09 and 12.15±4.14, respectively. A significant linear correlation was observed between the Cho/Cr ratio and the expression of Ki-67. The MRS features of meningiomas were as follow: Cho increased markedly, Cr decreased evidently. Conclusion: 1H-MRS is a useful diagnostic method for determining the proliferation or malignant potential of meningiomas according to the Cho/Cr ratio and the latter is correlated to the Ki-67 value.

导出引用

史瑞华;翟仁友;钱晓军;鲁万红;顾华. 脑膜瘤磁共振波谱Cho/Cr比值与Ki-67核抗原表达的相关性研究[J]. 中国临床医学影像杂志. 2008, 19(12): 855-857

SHI Rui-hua;ZHAI Ren-you;QIAN Xiao-jun;LU Wan-hong;GU Hua. Correlation study between Cho/Cr value of MRS and Ki-67 labeling index in meningiomas[J]. Journal of China Clinic Medical Imaging. 2008, 19(12): 855-857

中图分类号： Ｒ739.45 Ｒ445.2