摘要
目的：确定自动移床主髂动脉和下肢动脉磁共振增强血管成像（CE MRA）的对比剂最佳注射速度。材料与方法：15名健康志愿者随机分成3组。采用1.5T MRI扫描仪进行主髂动脉和下肢动脉三站CE MRA成像。马根维显0.25mmol/kg经肘静脉注射，一半对比剂以2.0ml/s的速度注射，另一半分别以1.0ml/s、 0.8ml/s和0.5ml/s注入。应用自动移床和对比剂自动跟踪软件进行图像的自动采集，根据主要动脉分枝的显示情况、有无静脉增强重叠影以及主要动脉的信号噪声比（SNR）和对比噪声比（CNR），对每组图像进行定性和定量分析。结果：所有受试者均获得了主髂动脉到小腿远端动脉树的图像。3组主要动脉分枝的SNR和CNR进行组间t检验，P＞0.05，无显著性差异，但第三组SNR和CNR的均值最高。第一组大腿段和小腿段静脉增强较严重，第二组有部分增强，第三组小腿远端有轻度的浅静脉强化。与第一组和第二组比较，第三组静脉强化最少，三组间静脉增强评分进行比较有显著性差异，P＜0.05。结论：采用2.0ml/s和0.5ml/s对比剂双相注射速度，可以获得动脉显示好、静脉增强最少的主髂动脉和下肢动脉CE MRA图像。
Abstract
Objective: To determine the optimal biphasic bolus rate based on automated table movement for aorto-iliac and lower extremity arteries of contrast-enhanced magnetic resonance angiography(CE MRA). Materials and Methods: Fifteen healthy volunteers were given CE MRA examinations in aorto-iliac and lower extremity arteries in three station technique. A 1.5T scanner with a 3D SPGRE was used; the whole body coil was selected for the entire study. Total 30～40ml gadopentetate dimeglumine was administered automatically by a power injector. A biphasic bolus protocol was designed, the first half of the contrast agent volume was injected at a rate of 2.0ml/s, and the second half was injected at a rate of 1.0ml/s in group 1(n=5), 0.8ml/s in group 2(n=5), 0.5ml/s in group 3(n=5), then was flushed with 20ml of normal saline at a rate of 2.0ml/s. For automated table movement and bolus-chase MR angiography, commercially available software was used. The qualitative and quantitative data of image quality were analyzed using student t test analysis. Statistical significance was established at P<0.05. Results: The entire arterial tree from the aorto-iliac arteries to the dorsal calf arteries was displayed. All MR angiographic examinations yielded good results with diagnostic image quality. Signal noise ratio(SNR) and contrast noise ratio(CNR) were calculated on the basis of signal intensity measurements in region of interest. There were no significant differences for SNR and CNR values among all the groups(P>0.05), but the highest SNR and CNR values were found in group 3. The venous enhancement in the calf and thigh was most obvious in group 1, partially seen in group 2, and few showed in group 3. There were statistical differences between venous enhancement scores in group 3 and those in group 1 and group 2(P<0.05). Conclusion: These findings suggest that with the biphasic bolus rate of 2.0ml/s followed by 0.5ml/s, optimal image quality is acquired and venous enhancement is minimized.
关键词
动脉 /
磁共振血管造影术
Key words
Arteries /
Magnetic resonance angiography
程 英;张远芳;郭岳霖;关计添;方文辉;刘啟泽.
自动移床主髂动脉及下肢动脉CE MRA成像的初步研究[J]. 中国临床医学影像杂志. 2008, 19(3): 189-192
CHENG Ying;ZHANG Yuan-fang;GUO Yue-lin;GUAN Ji-tian;FANG Wen-hui;LIU Qi-ze.
Aorto-iliac and lower extremity arteries: contrast-enhanced MR angiographyin healthy volunteers with automated table movement[J]. Journal of China Clinic Medical Imaging. 2008, 19(3): 189-192
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