摘要
目的：探讨兔VX2肝癌的DWI成像技术及成像特征。方法：新西兰大白兔25只，采用组织块、细胞悬液种植的方法制成24只肝癌模型，使用Philips 1.5T磁共振扫描仪行常规MR扫描后，采用EPI-SE序列、SENSE技术，取b值为100、200、300、400、500、600s/mm2分别行DWI扫描，选取病灶与周围正常肝组织的感兴趣区（ROI），分别测量表面扩散系数（ADC）值，进行统计学分析。结果：成功制成24只肝癌模型，共28个病灶，在DWI图上，病灶信号高于周围肝实质，在ADC图上则相反，病灶ADC值低于周围肝实质。当ｂ值为100、200、300、500、600s/mm2时，VX2瘤组织、正常肝组织ADC值差异有统计学意义，VX2瘤组织ADC值低于正常肝组织。当b值为200、300、400s/mm2时VX2瘤组织ADC值差异无统计学意义，当b值取300、400、500、600s/mm2时正常肝组织ADC值差异无统计学意义。结论：兔VX2肝癌模型适合于DWI成像研究，DWI序列既能通过组织不同的信号强度观察解剖，又能通过ADC值对组织进行量化分析，属于形态和功能双重成像，有可能对不同方法治疗后的兔VX2肝癌的疗效评价进行定性分析。
Abstract
Objective: To discuss the imaging technology and characteristic of diffusion-weighted imaging in rabbit models of hepatic VX2 tumors. Methods: Twenty-five New Zealand rabbits, 24 were implanted with VX2 tumor by tissue block or cell suspension into liver. After routine scans were performed on 1.5T MR scanner, using EPI-SE series and SENSE technology, b value of 100, 200, 300, 400, 500 and 600s/mm2 were used respectively on DWI scanning. Choose the ROI of the VX2 tumor tissue and normal liver tissue and then measure ADC values respectively for statistical analysis. Results: Twenty-four rabbit models of hepatic VX2 tumors were implanted successfully and 28 lesions were detected. In DWI map, the lesions’ signal higher than that of the surrounding liver parenchyma, on the contrary, the lesions’ ADC value was lower than that of the surrounding liver parenchyma in ADC map. In the b value of 100, 200, 300, 500, 600s/mm2, the difference of ADC value on VX2 tumor tissue and normal liver tissue was statistically significant, VX2 tumors’ ADC value lower than normal liver tissue. When the b value was 200, 300, 400s/mm2, the difference of ADC value in VX2 tumor tissue was not statistically significant, when the b value was 300, 400, 500s/mm2, the difference of ADC value in normal liver tissue was not statistically significant. Conclusion: The rabbit models of hepatic VX2 tumors were suitable for DWI imaging studies, DWI sequence is helpful in observing anatomy by different signal intensity and can conduct a quantitative analysis through the ADC value, it belongs to morphology and function imaging and will be possible for qualitative analysis of rabbit models of hepatic VX2 tumors by different treatments.
关键词
肝肿瘤 /
实验性 /
兔 /
磁共振成像
Key words
Liver neoplasms /
experimental /
Rabbits /
Magnetic resonance imaging
江新青;吴红珍;谢 琦;陈 亮;陈阿梅;郑力强.
兔VX2肝癌MR扩散加权成像的实验研究[J]. 中国临床医学影像杂志. 2008, 19(5): 309-312
JIANG Xin-qing;WU Hong-zhen;XIE Qi;CHEN Liang;CHEN A-mei;ZHENG Li-qiang.
Experimental study of diffusion-weighted imaging in rabbit models of hepatic VX2 tumors[J]. Journal of China Clinic Medical Imaging. 2008, 19(5): 309-312
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
