摘要
目的：探讨PET/CT显像在体部恶性肿瘤质子放射治疗疗效评价中的临床价值。方法：22例经最终病理检查及临床诊断的恶性肿瘤患者，质子放射治疗前后各行1次18F-FDG PET/CT显像，以最大标准摄取值（SUVmax）的变化来评价质子放射治疗的疗效，并与质子放射治疗后CT等常规影像及临床随访结果进行对比分析。结果：①质子放射治疗前，PET/CT显像共发现22例肿瘤患者46处病灶，SUVmax在6.9~37之间（16.36±9.35），常规影像发现病灶38处。②质子放射治疗后，46处病灶代谢活度均降低，SUVmax降低24%～88%，SUVmax在2.5~24之间（6.64±5.37）。而CT等常规影像显示41%（19/46）肿块消失或缩小，而59%（27/46）的肿块无明显改变。临床随访3~9个月证实经质子放射治疗的46处病灶均得到有效控制。结论：PET/CT显像可以早期、有效地评价恶性肿瘤质子放射治疗的效果。
Abstract
Objective: To investigate the clinical value of PET/CT for the therapeutic efficacy of proton radiation therapy of body malignant tumors. Methods: Twenty-two patients with body malignant tumors, all are confirmed by pathology or clinic. The 18F-FDG PET/CT scan was performed both before and after proton radiation therapy. With maximal standard uptake value(SUVmax) to evaluate the efficacy of the treatment, conventional CT imaging and clinical follow-up results were analyzed after proton radiation therapy. Results: ①Before proton radiation therapy, 46 lesions were found in the PET/CT imaging of 22 cases with tumor. SUVmax is between 6.9~37(16.36±9.35) and 38 lesions were found in the conventional imaging. ②After proton radiation therapy, the metabolic activity of 46 lesions is decreased with SUVmax dropped 24%~88% between 2.5~24(6.64±5.37). CT and conventional imaging showed that 41%(19/46) tumors were disappeared or reduced, and 59%(27/46) of the tumor did not change significantly. Clinical follow-up of 3~9 months confirmed that 46 lesions have been effectively controlled after the proton radiotherapy. Conclusion: PET/CT can early and effectively evaluate the therapeutic efficacy of proton radiation therapy.
关键词
肿瘤 /
体层摄影术 /
X线计算机 /
正电子发射断层显像术
Key words
Neoplasms /
Tomography /
X-ray computed /
Positron-emission tomography
刘 健;吕 杰;朱 滨;赵 涛;石志钢;孙 波.
FDG PET/CT显像评价体部恶性肿瘤质子放射治疗疗效[J]. 中国临床医学影像杂志. 2008, 19(6): 398-401
LIU Jian;LV Jie;ZHU Bin;ZHAO Tao;SHI Zhi-gang;SUN Bo.
Clinical application of FDG PET/CT to evaluate the therapeutic efficacy of proton radiation therapy in body tumors[J]. Journal of China Clinic Medical Imaging. 2008, 19(6): 398-401
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