脂膜超声造影剂增强兔肾VX2肿瘤显像及鉴别的实验研究

曾功君; 柳建华; 高云华; 刘政; 谭开彬; 吴梅

中国临床医学影像杂志 ›› 2008, Vol. 19 ›› Issue (6) : 412-414.

论著

脂膜超声造影剂增强兔肾VX2肿瘤显像及鉴别的实验研究

曾功君1，柳建华1，高云华2，刘政2，谭开彬2，吴梅1

作者信息 +

Experimental study on lipid ultrasound contrast agent in imaging and differentiating renal VX2 carcinoma

ZENG Gong-jun1, LIU Jian-hua1, GAO Yun-hua2, LIU Zheng2, TAN Kai-bin2, WU Mei1

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文章历史 +

摘要

目的：评价声学造影剂脂氟显对兔肾VX2肿瘤增强显像效果。方法：14只接种过VX2肾肿瘤的模型兔，经耳缘静脉团注脂氟显0.02ml/kg；使用二次谐波显像模式观察记录造影过程；用定性视觉评分和灰阶视频定量方法分析造影效果。结果：肿瘤视觉增强从5s开始，持续时间10~15min。视觉评分在造影后与造影前比较有显著差异。灰阶视频密度定量分析造影后VX2肿瘤灰阶值显著小于正常肾皮质（P<0.05）。结论：脂膜超声造影剂能有效增强兔肾VX2肿瘤显像，对假阳性有一定的鉴别诊断价值。

Abstract

Objective: To evaluate the imaging capability of lipid ultrasound contrast agent in imaging and differentiating renal VX2 carcinoma. Methods: Fourteen rabbits with VX2 carcinoma of left kidney were scanned by fundamental imaging and second harmonic imaging(SHI) after bolus injection of lipid ultrasound contrast agent(Zhifuxian 0.02ml/kg). The contrast-enhanced effect was estimated with qualitative vision and quantification gray-scale value. Results: The tumor was enhanced 5s after injection of ultrasound agent and lasted for 10~15 minutes. As to the qualitative vision there was statistically significant before and after contrast-enhanced. There was remarkable difference between renal cortex and renal tumor in gray-scale value after injection ultrasound agent. Conclusion: Lipid ultrasound contrast agent can effectively enhance the imaging of renal tumors and improve the detection of specificity.

导出引用

曾功君;柳建华;高云华;刘政;谭开彬;吴梅. 脂膜超声造影剂增强兔肾VX2肿瘤显像及鉴别的实验研究[J]. 中国临床医学影像杂志. 2008, 19(6): 412-414

ZENG Gong-jun;LIU Jian-hua;GAO Yun-hua;LIU Zheng;TAN Kai-bin;WU Mei. Experimental study on lipid ultrasound contrast agent in imaging and differentiating renal VX2 carcinoma[J]. Journal of China Clinic Medical Imaging. 2008, 19(6): 412-414

中图分类号： Ｒ737.11 Ｒ445.1