无多重对照校正的SPECT正常人控尿脑区研究

尹雅芙; 殷 波; 李雪娜; 秀毛範至; 沖崎貴琢; 佐滕顺一; 油野民雄; 李亚明; 周久贸

中国临床医学影像杂志 ›› 2008, Vol. 19 ›› Issue (7) : 457-458.

论著

无多重对照校正的SPECT正常人控尿脑区研究

尹雅芙¹，殷波²，李雪娜¹，秀毛範至³，沖崎貴琢³，佐滕顺一³，油野民雄³，李亚明¹，周久贸¹

作者信息 +

A SPECT study of cerebral regions controlling urinary continence in healthy men without correction for multiple comparisons

YIN Ya-fu¹, YIN Bo², LI Xue-na¹, Noriyuki Shuke³, Atsutaka Okizaki³,
Junichi Sato³, Tamio Aburano³, LI Ya-ming¹, ZHOU Jiu-mao¹

Author information +

文章历史 +

摘要

目的：应用⁹⁹Tc^m-HMPAO SPECT和NEUROSTAT（Neurological Statistical Image Analysis Software）软件包分析无多重对照校正条件下正常人的控尿脑激活区。方法：对15例右利手的健康男性自愿者（24～45岁）进行了SPECT扫描，每位自愿者均在排空膀胱的静息状态和膀胱充满尿液的控尿状态下接受两次扫描。控尿图像是由两次采集的数据相减而获得的。图像分析采用NEUROSTAT分析软件包，无多重对照校正P<0.005。结果：无多重对照校正P<0.005条件下，与静息状态相比，控尿状态下额叶、颞叶、前扣带回、扣带回、丘脑、岛叶、顶叶、枕叶等皮质及皮质下的广泛区域均呈现放射性升高趋势。结论：应用SPECT显像和脑功能影像分析软件NEUROSTAT研究发现，在无多重对照校正条件下，正常健康男性控尿的大脑控制与大脑皮质及皮质下的广泛区域相关。

Abstract

Abstract: Objective: The aim of this study was to identify the brain areas that control urinary continence in healthy men by 99Tcm-hexamethylpropylene amine oxime（⁹⁹Tc^m-HMPAO） SPECT without correction of multiple comparisons. Methods: SPECT scans were performed on fifteen right-handed healthy male volunteers aged 24～45 years. Each subject was scanned twice without movement in a supine position. 444MBq and 555MBq 99Tcm-HMPAO were separately injected intravenously during the following two conditions: resting state with empty bladder and urine withholding state with full bladder. The final image during urine withholding was obtained by subtracting the first scan data from the second. The images were analyzed by Neurological Statistical Image Analysis Software（NEUROSTAT） and displayed on Z-score images at a significant threshold of P<0.005 without correction for multiple comparisons. Results: In urine withholding state, as compared with resting, there was a significant increase in tracer activity in a vast network of cortical and subcortical regions, which include the frontal lobe, temporal lobe, caudate nucleus, thalamus, cingulate gyrus, anterior cingulate gyrus, insula, parietal lobe, occipital lobe. Conclusion: Our results suggest that a vast network of cortical and subcortical regions is associated with cerebral control of urinary continence.

导出引用

尹雅芙;殷波;李雪娜;秀毛範至;沖崎貴琢;佐滕顺一;油野民雄;李亚明;周久贸. 无多重对照校正的SPECT正常人控尿脑区研究[J]. 中国临床医学影像杂志. 2008, 19(7): 457-458

YIN Ya-fu;YIN Bo;LI Xue-na;Noriyuki Shuke;Atsutaka Okizaki;Junichi Sato;Tamio Aburano;LI Ya-ming;ZHOU Jiu-mao. A SPECT study of cerebral regions controlling urinary continence in healthy men without correction for multiple comparisons[J]. Journal of China Clinic Medical Imaging. 2008, 19(7): 457-458

中图分类号： Ｒ322.81 Ｒ817.4