摘要
目的：探讨氢质子磁共振波谱（1H-MRS）在轻度认知障碍（MCI）、Alzheimer病（AD）诊断中的作用。方法：对20例MCI患者、20例AD患者、20例正常对照者（NC）行单体素1H-MRS检查，采用激励回波采样模式（STEAM），大小为2cm×2cm×2cm，测定后扣带回、左额中回皮质区、左枕叶皮质区的N-乙酰天门冬氨酸（NAA）、胆碱（Cho）和肌醇（mI）与肌酸（Cr）的比值，并比较各组间NAA/Cr、mI/Cr、Cho/Cr比值的差别。结果：在后扣带回、左额中回皮质区，AD组与MCI组、AD组与NC组间NAA/Cr有显著性差异（P<0.05），MCI组、AD组、NC组3组间mI/Cr有显著性差异（P<0.05）。结论：在后扣带回、左额中回皮质区，MCI患者仅有mI/Cr增高，而AD患者mI/Cr增高的同时伴有NAA/Cr下降。1H-MRS能无创性提供MCI、AD患者脑部的代谢情况，有助于MCI、AD的早期诊断。
Abstract
Objective: To evaluate the role of proton magnetic resonance spectroscopy(1H-MRS) in the diagnosis of mild cognitive impairment(MCI) and Alzheimer’s disease(AD). Methods: A single voxel 1H-MRS studies were performed to 20 patients with MCI, 20 patients with AD, and 20 normal control volunteers. The mode of spectral acquisition was STEAM technique, localizing 2cm×2cm×2cm voxels in the posterior cingulate gyri, the middle frontal gyrus cortex and the left occipital cortex. The metabolites in the spectra collected for quantification included N-acetyl aspartate(NAA), choline(Cho), creatine(Cr) and myo-inositol(mI). The ratios of NAA/Cr, mI/Cr and Cho/Cr were calculated and compared among the groups. Results: NAA/Cr of the posterior cingulate gyri and the middle frontal gyrus cortex region in AD-MCI group, AD-NC group were significantly different(P<0.05). mI/Cr of the posterior cingulate gyri and the middle frontal gyrus cortex region in AD, MCI and NC groups were significantly different(P<0.05). Conclusion: We found the reduction of NAA/Cr ratio and the increase of mI/Cr ratio in the posterior cingulate gyri and the middle frontal gyrus cortex in patients with AD, but only the increase of mI/Cr ratio in patients with MCI. 1H-MRS could provide biochemical and metabolic information on patients with MCI and AD noninvasively, which is helpful for the early diagnosis of MCI and AD.
关键词
认知障碍 /
阿尔茨海默病 /
磁共振波谱学
Key words
Cognition disorders /
Alzheimer disease /
Magnetic resonance spectroscopy
唐翠松;李文彬;邓 敏;常 城;刘 佳;钟 远.
轻度认知障碍和Alzheimer病的1H-MRS分析[J]. 中国临床医学影像杂志. 2008, 19(9): 612-615
TANG Cui-song;LI Wen-bin;DENG Min;CHANG Cheng;LIU Jia;ZHONG Yuan.
1H-MRS changes in mild cognitive impairment and Alzheimer’s disease[J]. Journal of China Clinic Medical Imaging. 2008, 19(9): 612-615
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