经子宫动脉化疗栓塞术对宫颈癌VEGF、MVD的影响

张国玲; 赵新建; 高永昌

中国临床医学影像杂志 ›› 2008, Vol. 19 ›› Issue (9) : 646-648.

论著

经子宫动脉化疗栓塞术对宫颈癌VEGF、MVD的影响

张国玲，赵新建，高永昌

作者信息 +

Effect of transcatheter uterine arterial chemoembolization on VEGF, MVD of cervical carcinoma

ZHANG Guo-ling, ZHAO Xin-jian, GAO Yong-chang

Author information +

文章历史 +

摘要

目的：通过检测宫颈癌血管内皮生长因子（VEGF）及微血管密度（MVD）在经子宫动脉化疗栓塞术前后的表达，观察经子宫动脉化疗栓塞术对宫颈癌VEGF和MVD的影响。方法：采用免疫组织化学法，分别对42例宫颈癌患者经子宫动脉化疗栓塞术前后的肿瘤组织测定MVD及VEGF的表达。结果：本组患者经子宫动脉化疗栓塞术后VEGF阳性表达率自术前的67％（28/42）降至35％（15/42），同时其MVD计数明显降低（P<0．05）。结论：经子宫动脉化疗栓塞术能降低宫颈癌组织VEGF的表达，减少MVD计数，提示此方法可能抑制宫颈癌的生长，减少术后转移。

Abstract

Objective: To evaluate the influence of transcatheter uterine arterial chemoembolization on expression of vascular endothelial growth factor(VEGF) and micro vascular density(MVD) of cervical cancer. Methods: Immunohistochemical exam was performed to detect the expression of VEGF and MVD in 42 cases of cervical carcinoma before and after transcatheter uterine arterial chemoembolization. Results: After transcatheter uterine arterial chemoembolization, the expression of VEGF decreased from 67％(28/42) to 35％(15/42), while MVD also decreased remarkably(P<0．05). Conclusions: Transcatheter uterine arterial chemoembolization can decrease expression of VEGF and MVD and may able to suppress the growth and metastasis of cervical cancer.

导出引用

张国玲;赵新建;高永昌. 经子宫动脉化疗栓塞术对宫颈癌VEGF、MVD的影响[J]. 中国临床医学影像杂志. 2008, 19(9): 646-648

ZHANG Guo-ling;ZHAO Xin-jian;GAO Yong-chang. Effect of transcatheter uterine arterial chemoembolization on VEGF, MVD of cervical carcinoma[J]. Journal of China Clinic Medical Imaging. 2008, 19(9): 646-648

中图分类号： Ｒ737.33 Ｒ815