目的：通过对BAThy前体和BOC前体合成肿瘤增值示踪剂 3’-脱氧-3’-[18F]氟胸腺嘧啶（18F-FLT）合成产率的研究，探讨BOC前体在提高18F-FLT合成产率中的价值。方法：联合国内7家PET中心按照国内多中心研究的统一标准进行正电子示踪剂18F-FLT合成研究方面的合作，回旋加速器（MINItrace，GE Healthcare），全自动合成系统（TRACERlab FX F-N；GE Healthcare）。BAThy前体：5’-氧-苯甲酰基-2，3’-胸苷；BOC前体：3-N-t-叔丁氧羰基-1-[5’-O-（4，4’-二甲氧基三苯甲基）-2’-脱氧-3’-O-（4-硝基苯磺酰基）-β-D-苏型-呋喃戊糖基]胸腺嘧啶，通过18O（p，n）18F反应生产的18F-离子分别与两种前体进行标记反应并水解，用HPLC进行纯化得到18F-FLT，放化纯度>95%。结果：采用BAThy前体合成18F-FLT，平均合成产率为10.1%。采用BOC前体合成18F-FLT，平均合成产率为23.2%。结论：研究发现BOC前体更容易被18F-离子标记，平均产率比BAThy前体提高了130%。我们还研究了各个因素对于18F-FLT合成的影响，包括碱量与前体量的比、前体的溶剂、水解方式以及操作方法。由于参与的单位分布在国内各个不同的地区，基本能够消除地域因素对合成产率的影响，所得出的结果对于今后的研究有很好的指导意义。

Objective: By the study of the process of synthesizing the tracer of tumor cellular proliferation which was 3’-deoxy-3’-18F-flurorothymidine(18F-FLT), using BAThy-FLT-precursor and BOC-FLT-precursor, demonstrated that the BOC-FLT -precursor played an important role in improving the synthesis yield of 18F-FLT. Method: We cooperated with seven PET centers doing the research on synthesizing the radioactive tracer(18F-FLT) following the standardized protocols of the national multicenter clinical trial. Cyclotron(MINItrace, GE Healthcare) and fully automated synthesis system(TRACERlab FX F-N, GE Healthcare). The (5’-O-Benzoyl-2, 3’-anhydrothymidine) and {3-N-t-Butoxycarbonyl-[5’-O-(4,4’-dimethoxytriphenylmethyl)- 2’-deoxy-3’-the product of 18O(p,n) 18F, and then hydrolyzed. Product were purified by the HPLC, getting the 18F-FLT, radiochemical purity>95%. Results: Using BAThy-FLT-precursor to synthesize 18F-FLT, the mean synthesis yield is 10.1%. While using BOC-FLT-precursor to synthesize 18F-FLT, the mean synthesis yield is 23.2%. Conclusion: We found that BOC-FLT-precursor was easier to be marked by 18F-. The mean product yield was 130% more than BAThy-FLT-precursor. We also studied on the effect of some factors on product yield of 18F-FLT, including the ratio of alkali to precursor, the solvent of precursor, the hydrolyze method and operated method. As the collaborator in the domestic distributed in the different areas, it eliminated the regional difference on the product yield. The results of the research is a good guide.