摘要
[摘要] 目的：对比血管回声跟踪技术与血流介导的血管舒张功能检测方法对评价2型糖尿病（T2DM）患者血管内皮功能的价值。方法：对46例T2DM患者和30例正常人采用血管回声跟踪技术实时跟踪描记右侧肱动脉管壁的运动轨迹，测量肱动脉收缩期内径（Ds）、舒张期内径（Dd）、僵硬度（β）、弹性模量（Eρ）、顺应性（AC）、脉搏波传导速度（PWVβ）等参数；采用高分辨率超声检测T2DM组和对照组血流介导的肱动脉内皮依赖性血管舒张（FMD）和硝酸甘油介导的非内皮依赖性血管舒张（NTG）功能。其中24例T2DM患者在3个月降糖药物治疗后重新测量上述各指标。结果：β，Eρ及PWVβ T2DM组较对照组升高（P<0.01），AC及FMD功能较对照组降低（P<0.01），硝酸甘油介导的NTG功能两组间差异无统计学意义（P>0.05）。结论：血管回声跟踪技术与血流介导的血管舒张功能检测方法均能较好的评价T2DM患者血管内皮功能，两种方法具有良好一致性。
Abstract
Abstract: Objective: To study the value of ultrasonic E-Tracking imaging technology and the method of flow-mediated vasodilation in evaluating vascular endothelial function in type 2 diabetes mellitus(T2DM) comparatively. Methods: Forty-six T2DM and thirty normal controls were included. E-Tracking imaging technology was performed to follow the movement tracks of the right brachial arterial wall, parameters including internal systolic diameter(Ds), internal diastolic diameter(Dd), stiffness parameters(β), pressure-strain elastic modulus(Eρ), arterial compliance(AC), and one-point pulse wave velocity(PWVβ) were assessed. The dilation of brachial artery during reactive hyperaemia(with increased flow causing endothelium-dependent dilatation) and after sublingual nitroglycerin application NTG, causing endothelium-independent dilatation were measured using high resolution ultrasound. The same parameters were assessed after three months treatment with melbine in 24 cases of T2DM. Results: In the T2DM group, β, Eρ and PWVβ were significantly higher, and AC was significantly lower than those in the control group(P<0.01, comparatively). In T2DM, flow-mediated dilatation(FMD) decreased conspicuously compared with that in controls(P<0.01). The dilation by NTG was not significantly different between the two groups(P>0.05). Conclusion: E-Tracking imaging technology and the method of FMD can be used to evaluate vascular endothelial function in T2DM. Two methods have satisfactory concordance.
关键词
糖尿病 /
2型 /
内皮 /
血管 /
超声检查 /
多普勒 /
彩色
Key words
Diabetes mellitus /
type 2 /
Endothelium /
vascular /
Ultrasonography /
Doppler /
color
胡莉君;吕 清;马 红;王新房;廖云飞;余 帆.
血管回声跟踪技术与血流介导的血管舒张功能检测方法对评价2型糖尿病患者血管内皮功能的对比性研究[J]. 中国临床医学影像杂志. 2009, 20(4): 233-235
HU Li-jun;LV Qing;MA Hong;WANG Xin-fang;LIAO Yun-fei;YU Fan.
Comparison of the value of ultrasonic E-Tracking imaging and the method of flow-mediated vasodilation in evaluating vascular endothelial function in type 2 diabetes mellitus[J]. Journal of China Clinic Medical Imaging. 2009, 20(4): 233-235
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