摘要
目的：探讨肝细胞性肝癌（HCC）超声造影血流灌注定量参数与肿瘤微血管密度（MVD）的相关性。方法：46例HCC患者术前行超声造影检查，利用时间-强度曲线（TIC）进行定量分析，得出肝癌及癌旁组织的达峰时间（TTP）、峰值强度（PI），与术后病理免疫组织化学染色计数的MVD进行相关性分析。结果：46例HCC与癌旁组织的TTP平均值分别为（14.24±5.11）s及（25.34±9.11）s，PI平均值分别为（43.11±10.25）dB及（20.87±8.21）dB，MVD平均值分别为52.32±18.21及21.43±8.65。HCC术前TTP与术后MVD呈负相关（r=-0.75，P＜0.05），PI与MVD呈正相关（r=0.73，P＜0.05）。结论：HCC超声造影定量灌注参数PI、TTP与MVD的表达有良好的相关性，可作为术前评估HCC血管生成状况的指标。
Abstract
Objective: To explore the correlation between quantitation parameters of blood perfusion with contrast-enhanced ultrasound(CEUS) and microvessel density(MVD) in hepatocellular carcinoma(HCC). Methods: CEUS was examined before operation in 46 patients with HCC. Time-intensity curves(TIC) in 46 cases with HCC were analyzed to get the time to peak(TTP) and peak intensity(PI) of HCC and tissue around HCC. These parameters were analyzed correlatively with MVD counted with immunocytochemistry. Result: The mean TTP of HCC and tissue around HCC were (14.24±5.11)s and (25.34±9.11)s, the mean PI of HCC and tissue around HCC were (43.11±10.25)dB and (20.87±8.21)dB, the mean MVD of HCC and tissue around HCC were 52.32±18.21 and 21.43±8.65. The TTP before operation correlated inversely to MVD (r=-0.75, P＜0.05) of histological section after operation. The PI before operation was correlated positively to MVD (r=0.73, P＜0.05) of histological section after operation. Conclusions: The quantitative parameters of blood perfusion, TTP and PI, with calculated from CEUS was correlated to MVD. These parameters could be a potential indicator of angiogenesis of HCC before operation.
关键词
肝肿瘤 /
癌 /
肝细胞 /
超声检查 /
多普勒 /
彩色
Key words
Liver neoplasms /
Carcinoma /
hepatocellular /
Ultrasonography /
Doppler /
color
袁 惠;王 丹;陈红艳;牛锦东.
肝细胞性肝癌超声造影定量参数与微血管密度的相关性研究[J]. 中国临床医学影像杂志. 2009, 20(4): 255-257
YUAN Hui;WANG Dan;CHEN Hong-yan;NIU Jin-dong.
Correlative study between quantitative parameters of contrast-enhanced ultrasound and microvessel density in hepatocellular carcinoma[J]. Journal of China Clinic Medical Imaging. 2009, 20(4): 255-257
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