摘要
目的：对比研究18F-FDG PET-CT全身显像与99mTc-MDP全身骨骼显像对肺癌骨转移诊断的价值。方法：回顾性研究49例病理证实为肺癌的患者，男28例，女21例，平均年龄（58.9±10.8）岁，所有患者均于10天内分别行18F-FDG PET-CT全身显像与99mTc-MDP全身骨显像，最终骨转移癌诊断结果由手术病理、MR检查或临床随访半年以上病灶范围扩大或加重证实。结果：49例患者18F-FDG PET-CT与99mTc-MDP全身显像共检出异常病灶259处，其中被证实为转移灶228处，31处为良性病灶。18F-FDG PET-CT和99mTc-MDP SPECT诊断骨转移癌的灵敏度为90.8%和56.6%，特异性为93.5%和45.2%，准确性为91.1%和55.2%。结论：18F-FDG PET-CT全身显像对肺癌骨转移诊断的灵敏度、特异性及准确性均高于99mTc-MDP全身骨显像。
Abstract
Objective: To compare the diagnostic value of 18F-FDG PET-CT and 99mTc-MDP bone scintigraphy for the detection of bone metastases in patients with lung cancer. Methods: We examined 49 patients, 28 men, 21 women with lung cancer, mean age (58.9±10.8)years. All patients underwent both whole-body 18F-FDG PET-CT and 99mTc-MDP bone scintigraphy within 10 days. Bone metastases were verified either by pathological results or MR findings or follow-up more than half a year. Results: Bone metastases were confirmed in 228 of the 259 foci. The sensitivity for bone metastases using 18F-FDG PET-CT and 99mTc-MDP as 90.8% and 56.6% respectively, the specificity was 93.5% and 45.2% respectively. The accuracy was 91.1% and 55.2% respectively. Conclusion: The specificity and the overall accuracy of 18F-FDG PET-CT for the diagnosis of bone metastases in patients with lung cancer are higher than those of 99mTc-MDP bone scintigraphy.
关键词
肺肿瘤 /
肿瘤转移 /
骨肿瘤 /
正电子发射断层显像术 /
体层摄影术 /
发射型计算机 /
单光子
Key words
Lung neoplasms /
Neoplasm metastasis /
Bone neoplasms /
Positron-emission tomography /
Tomography /
emission-computed /
single-photon
徐微娜;辛 军;于树鹏;王晓明;郭启勇.
18F-FDG PET-CT与99mTc-MDP全身显像对肺癌骨转移癌诊断的对比研究[J]. 中国临床医学影像杂志. 2009, 20(5): 323-326
XU Wei-na;XIN Jun;YU Shu-peng;WANG Xiao-ming;GUO Qi-yong.
Comparison of 18F-FDG PET-CT and 99mTc-MDP bone scintigraphy in detection of bone metastasesof lung cancer[J]. Journal of China Clinic Medical Imaging. 2009, 20(5): 323-326
中图分类号：
Ｒ734.2
Ｒ738.1
R817.4
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