摘要
目的：探讨子宫颈癌的MRI动态增强特征，为子宫颈癌的多期增强扫描时相的选择提供参考信息。方法：选取25例临床病理证实为子宫颈癌的患者作为研究对象，同时以4例子宫颈肌瘤和10例女性志愿者作对照组，均行盆腔MRI平扫及动态增强扫描，选取感兴趣区绘制增强扫描时间－信号曲线（TIC），分别计算各感兴趣区在增强16s、32s、48s、64s、128s信号参数强化率（E）[（增强后的信号强度值-增强前的信号强度值）×100%/增强前的信号强度值]，用student-t检验统计分析各时间段强化率的差异，同时将TIC分为4种类型。结果：子宫颈癌在增强早期（0～32s）明显强化，与正常子宫颈肌层、子宫颈肌瘤的强化率有显著差异（P<0.05）。在增强扫描中、晚期（32～128s）子宫颈癌增强强化率与对照组无显著差异（P>0.05）。25例子宫颈癌中，22例TIC呈Ⅰ型，3例呈Ⅱ型。对照组TIC主要呈Ⅲ、Ⅳ型曲线。结论：MR动态增强扫描能够反应子宫颈癌组织的血供状态，应着重观察子宫颈癌增强早期（0～32s）时间段内宫颈癌的信号变化及强化率，有助于子宫颈癌的诊断及分期。
Abstract
Objective: To approach the characteristics of dynamic contrast-enhanced MR imaging in cervical cancer. To provide reference to contrast-enhanced phase choice in cervical cancer. Methods: Twenty-five cases with pathologically proved cervical cancer were served as study group, 4 cases with cervical leiomyoma and 10 volunteers as control group. Plain scan and dynamic contrast-enhanced MR scanning were given to the patients in the study as well as to the individuals in the control group. For imaging data analysis, ROI was selected and time-intensity curves(TIC) were derived from dynamic contrast-enhanced MR imaging of ROI, calculate ROI enhanced rate(E)＝(the post contrast-enhanced signal intensity-the precontrast-enhanced signal intensity)×100%/the precontrast-enhanced signal intensity. On statistics, we compared the differences of enhanced rate respectively at different time, 16s, 32s, 48s, 64s, 128s. The T-test was used, P<0.05 was considered statistically significant. TIC were divided into four types. Results: Almost all cervical cancer showed marked contrast-enhanced appearance in the early period(0~32s). There were significant difference in early enhanced rate between cervical cancer, normal stroma of cervix and leiomyoma(P<0.05), but there were no significant difference on enhanced rate in the intermediate and late phase(P>0.05). In 25 cases with cervical cancer, 22 cases had type Ⅰ curve, 3 cases had type Ⅱ curve. In the control group, almost belong to type Ⅲ and type Ⅳ curve. Conclusion: Dynamic contrast-enhanced MR imaging can reflect the blood supply of the tumor, to emphasize signal change and enhanced rate in the earlier period(0~32s). Dynamic contrast enhanced study is useful to make diagnosis.
关键词
宫颈肿瘤 /
磁共振成像
Key words
Cervix neoplasms /
Magnetic resonance imaging
张 弦;严志汉;虞志康;白光辉;毛传万.
子宫颈癌的MRI动态增强扫描特征分析[J]. 中国临床医学影像杂志. 2009, 20(7): 541-544
ZHANG Xian;YAN Zhi-han;YU Zhi-kang;BAI Guang-hui;MAO Chuan-wan.
The characteristics of dynamic contrast-enhanced MR imaging in cervical cancer[J]. Journal of China Clinic Medical Imaging. 2009, 20(7): 541-544
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