乳腺癌超声特征与分子生物学指标的相关性研究

吴俊; 曹永政; 彭格红

中国临床医学影像杂志 ›› 2009, Vol. 20 ›› Issue (9) : 689-692.

论著

乳腺癌超声特征与分子生物学指标的相关性研究

吴俊1，曹永政2，彭格红2

作者信息 +

The correlation study on ultrasonographic features and molecular biology of breast cancer

WU Jun1, CAO Yong-zheng2, PENG Ge-hong2

Author information +

文章历史 +

摘要

目的：探讨乳腺癌超声特征与分子生物学指标雌激素受体（ER）、孕激素受体（PR）、CerbB-2之间的相关性。方法：对术前应用超声检查的160例乳腺癌患者术后的肿瘤标本应用免疫组化法检测ER、PR及CerbB-2蛋白表达。结果：在乳腺癌超声显示肿块≥2.5cm及肿块＜2.5组中的ER、PR阳性表达率差异无统计学意义（P＞0.05)， CerbB-2阳性表达率，肿块≥2.5cm组高于肿块＜2.5cm组，且差异有统计学意义（P＜0.05）。毛刺征组ER表达的阳性率高于无毛刺征组，且差异有显著性意义（P＜0.05），毛刺征组与无毛刺征组PR、CerbB-2的阳性表达率差异无显著性（P＞0.05）。超声显示富血供组、有淋巴结转移组ER、PR阳性率明显低于乏血供组、无淋巴结转移组（P＜0.05）；CerbB-2阳性率则高于对应病例（P＜0.05）。结论：乳腺癌超声特征与ER、PR、CerbB-2的表达具有相关性，两者结合起来可以作为评价乳腺癌恶性程度和预后判定的一种有价值的新方法。

Abstract

Objective: To investigate the correlation between ultrasonographic features and molecular biology markers(ER, PR, CerbB-2) of breast cancer. Methods: The expressions of ER, PR and CerbB-2 in tumor tissue of 160 cases with breast cancer who were examined by ultrasonography in preoperation were detected by immunohistochemical techniques. Results: The positive expression rates of ER, PR were not significantly different between group of tumor size≥2.5cm and group of tumor size＜2.5cm by ultrasound examination(P＞0.05). The positive expression rate of CerbB-2 in group of tumor size≥2.5cm was higher than that in group of tumor size＜2.5cm, and was significantly different(P＜0.05). The positive expression rate of ER in group with spicula was higher than that without spicular edge, and was significantly different(P＜0.05). The positive expression rates of PR, CerbB-2 were not significantly different between spicular edge group and without spicular group(P＞0.05). The positve expression rates of ER, PR in patients with sufficient blood supply, axillary lymph nodes metastasis were lower than those with insufficient blood supply and no lymph node metastasis, but the positive of CerbB-2 was higher. Conclusion: The ultrasonographic features of breast cancer show correlation with the expressions of ER, PR, CerbB-2. Combination with these may viewed as a new valuable method to investigate malignant extent and prognostic evaluation in breast cancer.

导出引用

吴俊;曹永政;彭格红. 乳腺癌超声特征与分子生物学指标的相关性研究[J]. 中国临床医学影像杂志. 2009, 20(9): 689-692

WU Jun;CAO Yong-zheng;PENG Ge-hong. The correlation study on ultrasonographic features and molecular biology of breast cancer[J]. Journal of China Clinic Medical Imaging. 2009, 20(9): 689-692

中图分类号： Ｒ737.9 Ｒ445.1