摘要
目的：探讨MR首过灌注剂量及延迟扫描最佳成像时间，以获得较好心肌灌注图像及最佳延迟增强图像。方法：采用1.5T磁共振扫描仪行不同剂量（0.05mmol/kg组与0.1mmol/kg组）的首过灌注及不同延迟增强时间扫描，并对结果行统计学分析。结果：首过灌注剂量0.05mmol/kg组与0.1mmol/kg组，两组显示的心肌灌注降低或缺损区节段数有统计学差别（P<0.05）。不同延迟增强扫描时间数据显示：①在10min与5min时、40min与30min时的信号值有统计学意义；②5～10min是心肌缺损区信号值不断上升的一个阶段，10～30min信号值相对较平稳，30～40min心肌缺损区的信号值较前呈明显下降趋势。结论：首过灌注剂量0.1mmol/kg较0.05mmol/kg更利于检出缺血心肌；延迟增强扫描时间以10～30min之间的图像质量为最佳；有助于MRI更好的应用及心肌活性评价。
Abstract
Objective: To investigate the dose of first-pass perfusion and the best delayed scanning time. Thereby, the purpose is to get a better cardiac perfusion MRI images and the best delay-enhanced images. Method: Five experimental pigs with myocardial infarction underwent two MR myocardial first-pass perfusion imaging, the contrast agent dose were 0.05mmol/kg and 0.1mmol/kg respectively. Ten experimental pigs with myocardial infarction underwent delayed enhanced MR imaging at 5min, 10min, 30min, 40min time point. The results were analyzed statistically. Result: There was statistical difference(P<0.05) between the two groups(0.05mmol/kg and 0.1mmol/kg) in detection of the myocardial perfusion decrease or defect on the first-pass MR perfusion imaging. The data of the delayed enhancement MR imaging in different scanning time showed. ①The signal values were statistically significant between 10 minutes and 5 minutes, 40 minutes and 30 minutes; ②The signal values of myocardial infarction showed rise in the stage of 5～10 minutes; and the signal values were relatively stable in the 10～30 minutes; During the stage of 30～40 minutes, the signal value of myocardial infarction showed a clear downward trend compared with the previous time. Conclusion: The perfusion imaging quality of the dose of the 0.1mmol/kg group is better than the 0.05mmol/kg group. It can detect more myocardial perfusion defects. Delayed time between 10～30min is the best scanning time to the delayed enhancement MR imaging. These are helpful in the assessment of myocardial viability using MR first-pass myocardial perfusion imaging and delayed enhancement MR imaging.
关键词
心肌梗塞 /
动物实验 /
猪 /
磁共振成像
Key words
Myocardial infarction /
Animal experimentation /
Swine /
Magnetic resonance imaging
杨新焕;赵新湘;闫 东;袁曙光.
猪心梗模型MR首过灌注及延迟成像的技术探讨[J]. 中国临床医学影像杂志. 2010, 21(10): 697-700
YANG Xin-huan;ZHAO Xin-xiang;YAN Dong;YUAN Shu-guang.
The technology of first-pass perfusion MR imaging and delayed enhanced MR imaging in the swine myocardial infarction model: a preliminary study[J]. Journal of China Clinic Medical Imaging. 2010, 21(10): 697-700
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