摘要
目的：利用高频超声监测激素治疗对绝经后及绝经过渡期妇女乳腺的影响并评价其临床价值。方法：将绝经期及绝经过渡期妇女分为激素治疗组及安慰剂组，利用超声观察其乳腺腺体厚度、导管直径、腺体结构的变化。结果：①激素治疗后乳腺腺体厚度无明显变化，安慰剂组腺体变薄，具有显著性差异（P<0.01）；②激素治疗组与安慰剂组导管直径均明显扩张，具有显著性差异（P<0.01）；③激素治疗组与安慰剂组乳腺腺体结构的改变无明显差异（P>0.05），腺体结构的改变与乳腺癌无明显相关性。结论：长期小剂量激素治疗不增加乳腺癌的发生率，激素治疗期间利用超声密切监测乳腺结构的变化是一种简便易行且确实可靠的方法。
Abstract
Objective: To investigate the effects of breasts in post-menopausal women under hormone therapy(HT) by using ultrasonography and to evaluate its clinical value. Methods: During the post-menopausal and transition period, women were divided into two study groups, HT group and control group. Using ultrasonography to monitor the changes of glandular section thickness, breast duct width and breast structure in both breasts. Results: ①The breast glandular section thickness in the HT group has no significantly change. The breast glandular section thickness became thinner in the control group and there was a significant difference(P<0.01). ②The breast duct width had broadened in all groups(P<0.01). ③There was no obvious different in the breast structure between the HT group and control group. There is no obvious correlation between breast structure changes and mammary carcinoma. Conclusions: It seems that low dose HT has no obvious effect on occurences of mammary carcinoma at long-term. To monitor the breasts by ultrasound is a simple and reliable method during HT.
关键词
乳腺 /
人 /
激素替代疗法 /
超声检查
Key words
Mammary glands /
human /
Hormone replacement therapy /
Ultrasonography
莎仁高娃;姜 颖;姜玉新;林守清;孙爱军;王亚平.
超声监测激素治疗对中老年妇女乳腺的影响[J]. 中国临床医学影像杂志. 2010, 21(11): 770-773
SHAREN Gao-wa;JIANG Ying;JIANG Yu-xin;LIN Shou-qing;SUN Ai-jun;WANG Ya-ping.
Ultrasonographic observation of the breast in older women during hormone therapy[J]. Journal of China Clinic Medical Imaging. 2010, 21(11): 770-773
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