应用高频超声评价辛伐他汀对动脉粥样硬化血管内皮功能的影响

杨欣; 王薇; 曹霞; 郑春梅; 马春燕; 任卫东

中国临床医学影像杂志 ›› 2010, Vol. 21 ›› Issue (8) : 547-548.

论著

应用高频超声评价辛伐他汀对动脉粥样硬化血管内皮功能的影响

杨欣1，王薇1，曹霞1，郑春梅1，马春燕2，任卫东2

作者信息 +

Evaluation the effect of simvastatin on vascular endothelial function by high frequency sonography in atherosclerotic rabbits

YANG Xin1, WANG Wei1, CAO Xia1, ZHENG Chun-mei1, MA Chun-yan2, REN Wei-dong2

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文章历史 +

摘要

目的：应用高频超声评价辛伐他汀对动脉粥样硬化（AS）兔血管内皮功能的影响。方法：50只兔随机分为3组：A组为对照组（5只）；B组为AS模型组（25只）；C组为辛伐他汀治疗组（20只）。超声检测不同时期各组兔的血管内皮依赖性舒张功能（EDD）和血管内皮非依赖性舒张功能（NEDD），并进行了相关的血脂测定及病理检查。结果：辛伐他汀治疗组兔的血脂水平明显减低，EDD较AS组明显改善，12周以后NEDD较AS组有显著差异。结论：辛伐他汀可以保护血管内皮功能，减轻AS病变程度。高频超声是评价药物对血管内皮功能影响的良好方法。

Abstract

Objective: To assess the effect of simvastatin on vascular endothelial function by high frequency sonography. Methods: Fifty rabbits were randomly divided into control group(A group) and atherosclerotic group(B group) and simvastatin group(C group). Endothelial dependent dilation(EDD) and non-endothelial dependent dilation(NEDD) were measured with high resolution sonography at different time. Results: After intervention of simvastatin, the blood lipid decreased, EDD function was obviously improved, and NEDD was improved after 12 weeks. There was significant difference between the two groups. Conclusions: Simvastatin can improve endothelial function. High frequency sonography can be used to assess the effect of drug therapy on endothelial function.

导出引用

杨欣;王薇;曹霞;郑春梅;马春燕;任卫东. 应用高频超声评价辛伐他汀对动脉粥样硬化血管内皮功能的影响[J]. 中国临床医学影像杂志. 2010, 21(8): 547-548

YANG Xin;WANG Wei;CAO Xia;ZHENG Chun-mei;MA Chun-yan;REN Wei-dong. Evaluation the effect of simvastatin on vascular endothelial function by high frequency sonography in atherosclerotic rabbits[J]. Journal of China Clinic Medical Imaging. 2010, 21(8): 547-548

中图分类号： R543.5 R445.1